Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.68 |
| ▸ | AURKA | O14965 | 1/20 | 0.68 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.68 |
| ▸ | CDK8 | P49336 | 1/20 | 0.68 |
| ▸ | NEK2 | P51955 | 1/20 | 0.68 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.68 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.68 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.68 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.68 |
| ▸ | MPO | P05164 | 1/20 | 0.51 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 2/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | RPA1 | P27694 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29161027 | 0.86 | CHEK1 (0.56) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL31457212 | 0.86 | CHEK1 (0.53) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL6416275 | 0.82 | MEN1 (0.58) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL23320456 | 0.81 | CHEK1 (1.00) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL9910899 | 0.81 | CHEK1 (0.70) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL23320433 | 0.79 | MPO (0.49) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL30636856 | 0.79 | RIPK1 (0.51) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL1563562 | 0.76 | KDM5A (0.48) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| SCHEMBL28643520 | 0.76 | MPO (0.49) | CHEK1AURKACSNK1A1CDK8NEK2 | |
| Methane SCHEMBL27733031 | 0.75 | KDM5A (0.47) | CHEK1AURKACSNK1A1CDK8NEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1826319-A | Aryl-heteroaromatic compounds, compositions comprising them and use | AVENTIS PHARMA (FR) | 2006-08-30 | — | — | CN | disclosed |
| US-20050020593-A1 | Aryl-heteroaromatic compounds, compositions comprising them and use | AVENTIS PHARMA (FR) | 2005-01-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050020593-A1 | Aryl-heteroaromatic compounds, compositions comprising them and use | TUBB3, TUBB, TUBB1 | CHEK1 468/4885AURKA 110/4885CSNK1A1 382/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.