Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.54 |
| ▸ | RAB9A | P51151 | 8/20 | 0.54 |
| ▸ | MAPT | P10636 | 4/20 | 0.54 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL824375 | 0.77 | NPC1 (0.69) | NPC1RAB9AMAPTPSMB8SMN1; SMN2 | |
| SCHEMBL29531707 | 0.77 | NPC1 (0.69) | NPC1RAB9AMAPTPSMB8SMN1; SMN2 | |
| SCHEMBL879171 | 0.76 | NPC1 (0.54) | NPC1RAB9AMAPTPSMB8SMN1; SMN2 | |
| SCHEMBL5924699 | 0.76 | NPC1 (0.54) | NPC1RAB9AMAPTPSMB8SMN1; SMN2 | |
| SCHEMBL4188069 | 0.74 | DDAH1 (0.59) | NPC1RAB9AMAPTPSMB8SMN1; SMN2 | |
| SCHEMBL3083786 | 0.73 | PSMB8 (0.68) | NPC1RAB9AMAPTPSMB8SMN1; SMN2 | |
| SCHEMBL6445384 | 0.71 | NPC1 (0.54) | NPC1RAB9AMAPTPSMB8SMN1; SMN2 | |
| SCHEMBL6445389 | 0.71 | NPC1 (0.54) | NPC1RAB9AMAPTPSMB8SMN1; SMN2 | |
| SCHEMBL9542349 | 0.71 | NPC1 (0.54) | NPC1RAB9AMAPTPSMB8SMN1; SMN2 | |
| SCHEMBL474946 | 0.71 | NPC1 (0.54) | NPC1RAB9AMAPTPSMB8SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1395 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110655526-A | Cephalosporin-siderophore conjugates and methods of preparation and use thereof | 中国科学院上海药物研究所 | 2020-01-07 | — | — | CN | claimed |
| US-10000450-B2 | N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2018-06-19 | — | — | US | claimed |
| US-20170166524-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-06-15 | — | — | US | claimed |
| US-9611214-B2 | N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-04-04 | — | — | US | claimed |
| US-20140288065-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-09-25 | — | — | US | claimed |
| US-8815871-B2 | N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2014-08-26 | — | — | US | claimed |
| EP-2675800-A1 | FUNCTIONALIZED ANTHRACENE-CAPPED OLIGOTHIOPHENES AND ORGANIC SEMICONDUCTORS BASED ON THE SAME, USE THEREOF | Institute Of Chemistry, Chinese Academy Of Sciences (CN) | 2013-12-25 | — | — | EP | claimed |
| US-20130331583-A1 | FUNCTIONALIZED ANTHRACENE-CAPPED OLIGOTHIOPHENES AND ORGANIC SEMICONDUCTORS BASED ON THE SAME, USE THEREOF | Institute of Chemistry, Chinesse Academy of Sciences | 2013-12-12 | — | — | US | claimed |
| US-20130203750-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-08-08 | — | — | US | claimed |
| WO-2012079545-A1 | FUNCTIONALIZED ANTHRACENE-CAPPED OLIGOTHIOPHENES AND ORGANIC SEMICONDUCTORS BASED ON THE SAME, USE THEREOF | CHINESE ACADEMY OF SCIENCE INSTITUTE OF CHEMISTRY (CN) | 2012-06-21 | — | — | WO | claimed |
| EP-0285176-A2 | Silver halide color photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1988-10-05 | — | — | EP | claimed |
| EP-0281118-A2 | Silver halide photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1988-09-07 | — | — | EP | claimed |
| US-4737451-A | Silver halide color photographic material | FUJI PHOTO FILM CO., LTD. (JP) | 1988-04-12 | — | — | US | claimed |
| US-4614819-A | REACTING A THIOL ESTER COMPOUND WITH 7-AMINOCEPHALOSPORIN IN PRESENCE OF BORON TRIFLUORIDE | TOYAMA CHEMICAL CO., LTD. (JP) | 1986-09-30 | — | — | US | claimed |
| US-4587048-A | Process for the manufacture of 4-thioazetidinone compounds | CIBA-GEIGY CORPORATION (US) | 1986-05-06 | — | — | US | claimed |
| EP-0065488-B1 | PROCESS FOR THE PREPARATION OF 4-THIO-AZETIDINONE COMPOUNDS | CIBA-GEIGY AG (CH) | 1985-08-14 | — | — | EP | claimed |
| EP-0096795-A2 | N-aryl pyridones, their preparation and use | BAYER AG (DE) | 1983-12-28 | — | — | EP | claimed |
| US-4410522-A | BACTERICIDES | TOYAMA CHEMICAL CO., LTD. (JP) | 1983-10-18 | — | — | US | claimed |
| US-4200744-A | Substituted 7α-methoxy-7β[(2,3-dioxo-1-piperazinyl)carbonylaminophenylacetamido]cephalosporins | TOYAMA CHEMICAL COMPANY, LIMITED (JP) | 1980-04-29 | — | — | US | claimed |
| US-3930866-A | MAGENTA | FUJI PHOTO FILM CO., LTD. (JA) | 1976-01-06 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130203750-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | SLC6A2, TPH1, SLC6A3 | NPC1 701/4885RAB9A 503/4885MAPT 1263/4885 |
| US-10000450-B2 | N,N-substituted 3-aminopyrrolidine compounds useful as monoamines reuptake inhibitors | SLC6A2, TPH1, SLC6A3 | NPC1 701/4885RAB9A 503/4885MAPT 1263/4885 |
| US-20170166524-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | SLC6A2, TPH1, SLC6A3 | NPC1 701/4885RAB9A 503/4885MAPT 1263/4885 |
| US-20140288065-A1 | N,N-SUBSTITUTED 3-AMINOPYRROLIDINE COMPOUNDS USEFUL AS MONOAMINES REUPTAKE INHIBITORS | SLC6A2, TPH1, SLC6A3 | NPC1 701/4885RAB9A 503/4885MAPT 1263/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.