Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.59 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.56 |
| ▸ | CDK4 | P11802 | 2/20 | 0.56 |
| ▸ | CCND1 | P24385 | 2/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 2/20 | 0.56 |
| ▸ | PRKCA | P17252 | 9/20 | 0.56 |
| ▸ | PRKCG | P05129 | 8/20 | 0.56 |
| ▸ | PRKCB | P05771 | 8/20 | 0.56 |
| ▸ | PRKCD | Q05655 | 5/20 | 0.53 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | PRKACG | P22612 | 1/20 | 0.52 |
| ▸ | PRKACB | P22694 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.52 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.52 |
| ▸ | IDH1 | O75874 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3777462 | 0.92 | GSK3B (0.53) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL5756702 | 0.87 | GSK3B (0.71) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL5758314 | 0.84 | CAMK2D (0.62) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL3775416 | 0.82 | GSK3B (0.79) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL3775971 | 0.80 | GSK3B (0.61) | GSK3BCDK4CCND1CDK2PRKCA | |
| SCHEMBL8249349 | 0.77 | CDK2 (0.74) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL5755763 | 0.75 | GSK3B (0.64) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL5757844 | 0.75 | GSK3B (0.67) | GSK3BCDK4CCND1CDK2PRKCA | |
| SCHEMBL30319849 | 0.74 | CCNE2 (1.00) | GSK3BCCNE2CDK4CCND1CCNE1 | |
| SCHEMBL5686048 | 0.74 | CCNE2 (1.00) | GSK3BCCNE2CDK4CCND1CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362047-B1 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-05-17 | — | — | EP | disclosed |