Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 15/20 | 0.64 |
| ▸ | PRKCG | P05129 | 11/20 | 0.64 |
| ▸ | PRKCB | P05771 | 11/20 | 0.64 |
| ▸ | PRKCA | P17252 | 11/20 | 0.64 |
| ▸ | PRKCD | Q05655 | 6/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 3/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.43 |
| ▸ | CDK2 | P24941 | 1/20 | 0.43 |
| ▸ | KISS1R | Q969F8 | 1/20 | 0.41 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.41 |
| ▸ | IDH1 | O75874 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5756702 | 0.89 | GSK3B (0.71) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL3775971 | 0.81 | GSK3B (0.61) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL5758306 | 0.78 | GSK3B (1.00) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL5757611 | 0.75 | GSK3B (0.59) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL3771589 | 0.71 | PRKCA (0.84) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL5758532 | 0.71 | PRKCA (0.84) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL5758314 | 0.69 | CAMK2D (0.62) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL2946233 | 0.69 | PRKCA (0.51) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL3783864 | 0.68 | PRKCA (0.80) | GSK3BPRKCGPRKCBPRKCAPRKCD | |
| SCHEMBL3777462 | 0.68 | GSK3B (0.53) | GSK3BPRKCGPRKCBPRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362047-B1 | INDAZOLYL-SUBSTITUTED PYRROLINE COMPOUNDS AS KINASE INHIBITORS | ORTHO MCNEIL PHARM INC (US) | 2006-05-17 | — | — | EP | disclosed |