Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 16/20 | 0.59 |
| ▸ | ADAM17 | P78536 | 15/20 | 0.59 |
| ▸ | MMP9 | P14780 | 8/20 | 0.58 |
| ▸ | MMP3 | P08254 | 2/20 | 0.58 |
| ▸ | MMP13 | P45452 | 2/20 | 0.53 |
| ▸ | MMP2 | P08253 | 5/20 | 0.52 |
| ▸ | MMP7 | P09237 | 3/20 | 0.49 |
| ▸ | MMP12 | P39900 | 3/20 | 0.49 |
| ▸ | MMP14 | P50281 | 3/20 | 0.49 |
| ▸ | MMP15 | P51511 | 3/20 | 0.49 |
| ▸ | MMP16 | P51512 | 3/20 | 0.49 |
| ▸ | MMP26 | Q9NRE1 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5758974 | 0.91 | MMP1 (0.58) | MMP1ADAM17MMP9MMP3MMP13 | |
| SCHEMBL5760495 | 0.91 | ADAM17 (0.61) | MMP1ADAM17MMP3MMP13 | |
| SCHEMBL5756594 | 0.85 | MMP1 (0.72) | MMP1ADAM17MMP9MMP3MMP13 | |
| SCHEMBL5760549 | 0.83 | ALDH1A1 (0.47) | MMP1ADAM17 | |
| SCHEMBL5761953 | 0.83 | MMP1 (0.41) | MMP1ADAM17MMP9MMP3MMP13 | |
| SCHEMBL5757107 | 0.82 | ADAM17 (0.51) | MMP1ADAM17MMP9MMP3MMP13 | |
| SCHEMBL5761758 | 0.82 | L3MBTL1 (0.44) | MMP1ADAM17MMP13 | |
| SCHEMBL5762105 | 0.81 | MMP1 (0.48) | MMP1ADAM17MMP9MMP3MMP13 | |
| SCHEMBL6240371 | 0.81 | MMP1 (0.56) | MMP1ADAM17MMP9MMP3MMP13 | |
| SCHEMBL5759840 | 0.81 | ADAM17 (0.73) | MMP1ADAM17MMP9MMP3MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1104403-B1 | HYDROXY PIPECOLATE HYDROXAMIC ACID DERIVATIVES AS MMP INHIBITORS | PFIZER PROD INC (US) | 2006-05-10 | — | — | EP | claimed |