SCHEMBL5758619

SCHEMBL5758619

O=CN(CCc1ccc(Cl)c(Cl)c1)CCC(c1ccccc1)N1CCC(Cc2ccccc2)CC1

nearest known ligand 0.40

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
CCR5 P51681 2/20 0.40
TACR1 P25103 1/20 0.39
SIGMAR1 Q99720 2/20 0.38
SLC6A2 P23975 3/20 0.37
SLC6A4 P31645 3/20 0.37
SLC6A3 Q01959 3/20 0.37
BCL2 P10415 1/20 0.37
ALDH1A1 P00352 2/20 0.37
NPFFR1 Q9GZQ6 1/20 0.37
NPFFR2 Q9Y5X5 1/20 0.37
OPRM1 P35372 1/20 0.37
CYP2C9 P11712 1/20 0.36
CYP2C19 P33261 1/20 0.36
HTR2B P41595 1/20 0.36
MAPK14 Q16539 1/20 0.36
ATM Q13315 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5759400 0.82 CCR3 (0.45) TACR1SIGMAR1ALDH1A1NPFFR1NPFFR2
SCHEMBL5756618 0.78 ALDH1A1 (0.47) CCR5SIGMAR1SLC6A2SLC6A4SLC6A3
SCHEMBL6008839 0.77 CCR5 (0.46) CCR5SIGMAR1SLC6A2SLC6A4SLC6A3
SCHEMBL5758376 0.75 SIGMAR1 (0.49) CCR5TACR1SIGMAR1SLC6A2SLC6A4
SCHEMBL5756621 0.73 GRIN2B (0.48) SIGMAR1SLC6A2SLC6A4SLC6A3ALDH1A1
SCHEMBL5755428 0.70 SLC6A2 (0.47) CCR5SIGMAR1SLC6A2SLC6A4SLC6A3
SCHEMBL7405479 0.69 OPRK1 (0.52) CCR5SIGMAR1SLC6A2SLC6A4SLC6A3
SCHEMBL5759913 0.69 PRMT3 (0.56) SIGMAR1SLC6A2SLC6A4SLC6A3HTR2B
SCHEMBL5792327 0.69 ALDH1A1 (0.42) SIGMAR1ALDH1A1NPFFR1NPFFR2CYP2C9
Hydrochloric Acid SCHEMBL5756735 0.68 PRMT3 (0.55) SIGMAR1SLC6A2SLC6A4SLC6A3HTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1401821-A4 NOVEL PHENYLALKYL DIAMINE AND AMIDE ANALOGS SK CORP (KR) 2006-05-31 EP claimed
EP-1401821-A1 NOVEL PHENYLALKYL DIAMINE AND AMIDE ANALOGS SK Corporation (KR) 2004-03-31 EP claimed
WO-2002100848-A1 NOVEL PHENYLALKYL DIAMINE AND AMIDE ANALOGS SK CORPORATION (KR) 2002-12-19 WO claimed
EP-1401821-A4 NOVEL PHENYLALKYL DIAMINE AND AMIDE ANALOGS SK CORP (KR) 2006-05-31 EP disclosed
EP-1401821-A1 NOVEL PHENYLALKYL DIAMINE AND AMIDE ANALOGS SK Corporation (KR) 2004-03-31 EP disclosed
WO-2002100848-A1 NOVEL PHENYLALKYL DIAMINE AND AMIDE ANALOGS SK CORPORATION (KR) 2002-12-19 WO disclosed