Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PMP22 | Q01453 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GCLC | P48506 | 1/20 | 0.34 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.33 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.33 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.33 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29029474 | 1.00 | PMP22 (0.35) | PMP22CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL16782030 | 0.80 | PMP22 (0.42) | PMP22CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL28224631 | 0.80 | HDAC1 (0.48) | PMP22CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL890709 | 0.79 | CHRM1 (0.40) | PMP22CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL7241006 | 0.79 | CHRM1 (0.35) | PMP22CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL16588883 | 0.78 | PMP22 (0.37) | PMP22GCLCSLC1A3SLC1A2SLC1A1 | |
| SCHEMBL5022363 | 0.77 | CHRM1 (0.39) | PMP22CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL5014288 | 0.77 | CHRM1 (0.39) | PMP22CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL5013300 | 0.77 | CHRM1 (0.39) | PMP22CHRM1AKR1A1CHRM3HTR2A | |
| SCHEMBL1634572 | 0.77 | MMP2 (0.35) | PMP22CHRM1AKR1A1CHRM3HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 93 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140080788-A1 | NOVEL BICYCLIC NITROGEN CONTAINING HETEROARYL TGR5 RECEPTOR MODULATORS | BRISTOL-MYERS SQUIBB COMPANY | 2014-03-20 | — | — | US | claimed |
| US-20080161325-A1 | e.g. N1-[3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl]-3-(butylsulfonyl)-N1-(3-ethylbenzyl)-D-alaninamide dihydrochloride; inhibitors of amyloid beta-secretase enzyme; neurodegenerative diseases: Alzheimer's, Parkinson's diseases, Down's syndrome | ELAN PHARMACEUTICALS, INC. | 2008-07-03 | — | — | US | claimed |
| WO-2023192356-A1 | INTERMEDIATES USEFUL FOR THE PREPARATION OF AN LPXC ANALOG, AND PROCESSES FOR THEIR PREPARATION | ZOETIS SERVICES LLC (US) | 2023-10-05 | — | — | WO | disclosed |
| CN-116217426-A | Method for synthesizing S-fluorobutyramide from (R) -2-sulfonyl butyrate alkyl ester | 山东省农药科学研究院 | 2023-06-06 | — | — | CN | disclosed |
| CN-114591208-B | Synthetic method of gamma-mercapto-beta-sulfonyl methyl butyrate | 成都理工大学 | 2023-02-10 | — | — | CN | disclosed |
| CN-114591208-A | Synthetic method of gamma-mercapto-beta-sulfonyl methyl butyrate | 成都理工大学 | 2022-06-07 | — | — | CN | disclosed |
| US-20210053926-A1 | SUBSTITUTED BENZAZINONES AS ANTIBACTERIAL COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2021-02-25 | — | — | US | disclosed |
| EP-3765027-A1 | PYRIDINONE AND PYRIMIDINONE PHOSPHATES AND BORONATES USEFUL AS ANTIBACTERIAL AGENTS | Pfizer Inc (US) | 2021-01-20 | — | — | EP | disclosed |
| US-10781184-B2 | Substituted benzazinones as antibacterial compounds | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2020-09-22 | — | — | US | disclosed |
| WO-2019178305-A1 | PYRIDINONE AND PYRIMIDINONE PHOSPHATES AND BORONATES USEFUL AS ANTIBACTERIAL AGENTS | PFIZER INC. (US) | 2019-09-19 | — | — | WO | disclosed |
| CN-106573924-B | Isoxazoline hydroxamic acid derivs as LpxC inhibitor | 诺华股份有限公司 | 2019-06-25 | — | — | CN | disclosed |
| EP-1567489-A1 | PYRROLIDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004052851-A1 | PYRROLYDIN-2-ONE DERIVATIVES AS INHIBITORS OF THROMBIN AND FACTOR XA | GLAXO GROUP LIMITED (GB) | 2004-06-24 | — | — | WO | disclosed |
| EP-1389110-A2 | INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME | Avanir Pharmaceuticals (US) | 2004-02-18 | — | — | EP | disclosed |
| US-20030195194-A1 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | AVANIR PHARMACEUTICALS | 2003-10-16 | — | — | US | disclosed |
| WO-2002094203-A2 | INHIBITORS OF MACROPHAGE MIGRATION INHIBITORY FACTOR AND METHODS FOR IDENTIFYING THE SAME | AVANIR PHARMACEUTICALS (US) | 2002-11-28 | — | — | WO | disclosed |
| EP-0873123-A4 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIV PITTSBURGH (US) | 1999-02-03 | — | — | EP | disclosed |
| EP-0873123-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1998-10-28 | — | — | EP | disclosed |
| WO-1997017070-A1 | INHIBITORS OF PROTEIN ISOPRENYL TRANSFERASES | UNIVERSITY OF PITTSBURGH (US) | 1997-05-15 | — | — | WO | disclosed |
| EP-0576287-A1 | Cosmetic compositions | UNILEVER PLC (GB) | 1993-12-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195194-A1 | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same | MIF, MSR1, MMP12 | PMP22 3858/4885CHRM1 2131/4885AKR1A1 1011/4885 |
| US-20210053926-A1 | SUBSTITUTED BENZAZINONES AS ANTIBACTERIAL COMPOUNDS | LPXN, MLX, ZYX | PMP22 695/4885CHRM1 4834/4885AKR1A1 2705/4885 |
| US-10781184-B2 | Substituted benzazinones as antibacterial compounds | LPXN, MLX, ZYX | PMP22 695/4885CHRM1 4834/4885AKR1A1 2705/4885 |
| US-20140080788-A1 | NOVEL BICYCLIC NITROGEN CONTAINING HETEROARYL TGR5 RECEPTOR MODULATORS | GRK5, GPBAR1, GPR55 | PMP22 4772/4885CHRM1 114/4885AKR1A1 669/4885 |
| US-20080161325-A1 | e.g. N1-[3-amino-4-(3,5-difluorophenyl)-2-hydroxybutyl]-3-(butylsulfonyl)-N1-(3-ethylbenzyl)-D-alaninamide dihydrochloride; inhibitors of amyloid beta-secretase enzyme; neurodegenerative diseases: Alzheimer's, Parkinson's diseases, Down's syndrome | BACE1, APP, BACE2 | PMP22 409/4885CHRM1 2403/4885AKR1A1 2166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.