SCHEMBL5761877

SCHEMBL5761877

CC(=O)Oc1coc2ccccc12

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 2/20 0.50
NPC1 O15118 3/20 0.49
POLB P06746 2/20 0.49
MAOB P27338 9/20 0.49
SLC22A6 Q4U2R8 1/20 0.47
HTT P42858 3/20 0.46
MAOA P21397 1/20 0.46
KDM4E B2RXH2 4/20 0.44
ALDH1A1 P00352 3/20 0.44
TDP1 Q9NUW8 2/20 0.44
ESR1 P03372 1/20 0.44
ITGB3 P05106 1/20 0.44
ITGA2B P08514 1/20 0.44
HMGB1 P09429 1/20 0.44
HPGD P15428 1/20 0.44
GGT1 P19440 1/20 0.44
PTGS1 P23219 1/20 0.44
PTGS2 P35354 1/20 0.44
BLM P54132 1/20 0.44
NAPRT Q6XQN6 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Ammonia Solution, Strong SCHEMBL5763481 0.98 TSHR (0.49) TSHRNPC1POLBMAOBSLC22A6
SCHEMBL11668249 0.88 MAOB (0.57) TSHRNPC1POLBMAOBHTT
SCHEMBL13134182 0.85 MAOB (0.45) NPC1POLBMAOBMAOAKDM4E
SCHEMBL5164924 0.84 MAOB (0.54) TSHRNPC1POLBMAOBMAOA
SCHEMBL28071452 0.81 MAOB (0.46) TSHRNPC1POLBMAOBHTT
SCHEMBL4474110 0.79 MAOB (0.47) TSHRNPC1POLBMAOBMAOA
SCHEMBL31722071 0.79 MAOB (0.46) NPC1MAOBMAOAMAPTSMN1; SMN2
SCHEMBL4784331 0.79 MAOB (0.46) NPC1MAOBMAOAMAPTSMN1; SMN2
SCHEMBL7443073 0.79 MAOB (0.46) NPC1MAOBMAOAMAPTSMN1; SMN2
SCHEMBL12099914 0.78 MAPT (0.51) TSHRNPC1POLBMAOBKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3303312-B1 PROCESS FOR PREPARING (E)-(5,6-DIHYDRO-1,4,2-DIOXAZINE-3-YL)(2-HYDROXYPHENYL)METHANONE O-METHYL OXIME ARYSTA LIFESCIENCE CORP (JP) 2023-07-19 EP disclosed
EP-3303312-B1 PROCESS FOR PREPARING (E)-(5,6-DIHYDRO-1,4,2-DIOXAZINE-3-YL)(2-HYDROXYPHENYL)METHANONE O-METHYL OXIME ARYSTA LIFESCIENCE CORP (JP) 2023-07-19 EP disclosed
EP-3699178-A1 PROCESS FOR PREPARING FLUOXASTROBIN Arysta LifeScience Corporation (JP) 2020-08-26 EP disclosed
EP-3699178-A1 PROCESS FOR PREPARING FLUOXASTROBIN Arysta LifeScience Corporation (JP) 2020-08-26 EP disclosed
EP-3019495-B1 PROCESS FOR PREPARING FLUOXASTROBIN ARYSTA LIFESCIENCE CORP (JP) 2020-06-03 EP disclosed
EP-3019495-B1 PROCESS FOR PREPARING FLUOXASTROBIN ARYSTA LIFESCIENCE CORP (JP) 2020-06-03 EP disclosed
US-10087152-B2 Process for preparing (E)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone O-methyl oxime ARYSTA LIFESCIENCE CORPORATION (JP) 2018-10-02 US disclosed
US-20180148423-A1 Process for Preparing (E)-(5,6-Dihydro-1,4,2-Dioxazine-3-YL) (2-Hydroxyphenyl) Methanone O-Methyl Oxime ARYSTA LIFESCIENCE CORPORATION (JP) 2018-05-31 US disclosed
US-20180148423-A1 Process for Preparing (E)-(5,6-Dihydro-1,4,2-Dioxazine-3-YL) (2-Hydroxyphenyl) Methanone O-Methyl Oxime ARYSTA LIFESCIENCE CORPORATION (JP) 2018-05-31 US disclosed
US-20180148423-A1 Process for Preparing (E)-(5,6-Dihydro-1,4,2-Dioxazine-3-YL) (2-Hydroxyphenyl) Methanone O-Methyl Oxime ARYSTA LIFESCIENCE CORPORATION (JP) 2018-05-31 US disclosed
EP-1417168-A2 METHOD FOR PRODUCING 2-(HYDROXYPHENYL)-2-(ALKOXYIMINO)-N-METHYLACETAMIDE DERIVATIVES Bayer CropScience AG (DE) 2004-05-12 EP disclosed
US-6603025-B1 Used as intermediates for preparing fungicides BAYER AKTIENGESELLSCHAFT (DE) 2003-08-05 US disclosed
WO-2003055478-A1 GLYT1 TRANSPORTER INHIBITORS AND USES THEREOF IN TREATMENT OF NEUROLOGICAL AND NEUROPSYCHIATRIC DISORDERS SMITHKLINE BEECHAM P.L.C. (GB) 2003-07-10 WO disclosed
EP-1232151-B1 METHOD FOR PRODUCTION OF BENZOFURANONE OXIMES BAYER CROPSCIENCE AG (DE) 2003-07-09 EP disclosed
WO-2003014066-A2 METHOD FOR PRODUCING 2-(HYDROXYPHENYL)-2-(ALKOXYIMINO)-N-METHYLACETAMIDE DERIVATIVES BAYER CROPSCIENCE AG (DE) 2003-02-20 WO disclosed
EP-1232151-A1 METHOD FOR PRODUCTION OF BENZOFURANONE OXIMES Bayer Aktiengesellschaft (DE) 2002-08-21 EP disclosed
WO-2001036405-A1 METHOD FOR PRODUCTION OF BENZOFURANONE OXIMES BAYER AKTIENGESELLSCHAFT (DE) 2001-05-25 WO disclosed
US-6057357-A USEFUL IN TREATING PAIN, INFLAMMATION, PSORIASIS AND IRRITABLE BOWEL SYNDROME WARNER-LAMBERT COMPANY (US) 2000-05-02 US disclosed
WO-1998049158-A1 PERIPHERALLY SELECTIVE KAPPA OPIOID AGONISTS WARNER-LAMBERT COMPANY (US) 1998-11-05 WO disclosed
CN-1061152-A ESTER INHIBITORS CORTECH INC (US) 1992-05-20 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10087152-B2 Process for preparing (E)-(5,6-dihydro-1,4,2-dioxazin-3-yl)(2-hydroxyphenyl)methanone O-methyl oxime HMOX2, HAO2, HMOX1 TSHR 3439/4885NPC1 4598/4885POLB 447/4885
US-20180148423-A1 Process for Preparing (E)-(5,6-Dihydro-1,4,2-Dioxazine-3-YL) (2-Hydroxyphenyl) Methanone O-Methyl Oxime HMOX2, HAO2, HMOX1 TSHR 3409/4885NPC1 4586/4885POLB 451/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.