Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | IKBKB | O14920 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
| ▸ | HAVCR2 | Q8TDQ0 | 1/20 | 0.30 |
| ▸ | STAT1 | P42224 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5761739 | 0.90 | THRA (0.41) | THRBL3MBTL1THRAKMT2ATP53 | |
| SCHEMBL6475079 | 0.87 | THRA (0.34) | THRBL3MBTL1THRAKMT2ATP53 | |
| SCHEMBL7139293 | 0.83 | THRA (0.42) | THRBL3MBTL1THRAKMT2ATP53 | |
| SCHEMBL6457833 | 0.81 | ALDH1A1 (0.37) | THRBL3MBTL1THRAKMT2AKDM4E | |
| SCHEMBL6459710 | 0.79 | THRB (0.40) | THRBTHRAKMT2ATP53MAPT | |
| SCHEMBL5758004 | 0.73 | THRB (0.46) | THRBL3MBTL1THRAKMT2AATM | |
| SCHEMBL5759877 | 0.72 | L3MBTL1 (0.43) | L3MBTL1KMT2ATP53KDM4EGAA | |
| SCHEMBL6455277 | 0.69 | THRB (0.38) | THRBTHRAKMT2A | |
| SCHEMBL6454313 | 0.68 | THRB (0.40) | THRBTHRAKMT2AHPGDMAPT | |
| SCHEMBL5760209 | 0.68 | P2RX7 (0.40) | THRBTHRAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1206471-B1 | INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA NV (BE) | 2006-03-01 | — | — | EP | disclosed |
| EP-1206471-A1 | INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2002-05-22 | — | — | EP | disclosed |
| WO-2001010866-A1 | INTERLEUKIN-5 INHIBITING 6-AZAURACIL DERIVATIVES | JANSSEN PHARMACEUTICA N.V. (BE) | 2001-02-15 | — | — | WO | disclosed |