Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 3/20 | 0.44 |
| ▸ | CCR5 | P51681 | 2/20 | 0.43 |
| ▸ | RXRA | P19793 | 2/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.41 |
| ▸ | APEX1 | P27695 | 1/20 | 0.41 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL30982171 | 0.83 | SMN1; SMN2 (0.57) | KMT2AALDH1A1SMN1; SMN2POLBNPC1 | |
| Bromide SCHEMBL504672 | 0.83 | SMN1; SMN2 (0.57) | KMT2AALDH1A1SMN1; SMN2POLBNPC1 | |
| SCHEMBL29519716 | 0.81 | RAB9A (0.53) | KMT2AALDH1A1SMN1; SMN2POLBNPC1 | |
| SCHEMBL2469671 | 0.81 | RAB9A (0.53) | KMT2AALDH1A1SMN1; SMN2POLBNPC1 | |
| Hydrochloric Acid SCHEMBL29754142 | 0.79 | RAB9A (0.52) | KMT2AALDH1A1SMN1; SMN2POLBNPC1 | |
| Hydrochloric Acid SCHEMBL637319 | 0.79 | RAB9A (0.52) | KMT2AALDH1A1SMN1; SMN2POLBNPC1 | |
| Bromide SCHEMBL28093578 | 0.77 | MAPT (0.42) | ALDH1A1POLBTHRBRXRARXRB | |
| Bromide SCHEMBL1827960 | 0.74 | POLB (0.59) | KMT2AALDH1A1SMN1; SMN2POLBNPC1 | |
| Hydrochloric Acid SCHEMBL29266014 | 0.73 | ALDH1A1 (0.53) | ALDH1A1POLBSRD5A2KDM4EL3MBTL1 | |
| Hydrochloric Acid SCHEMBL3903181 | 0.73 | ALDH1A1 (0.53) | ALDH1A1POLBSRD5A2KDM4EL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060252800-A1 | Anti-leishmania agent | JAPAN SCIENCE AND TECHNOLOGY AGENCY (JP) | 2006-11-09 | — | — | US | disclosed |
| EP-1623981-A1 | ANTI-LEISHMANIA AGENT | Japan Science and Technology Corporation (JP) | 2006-02-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060252800-A1 | Anti-leishmania agent | RPL17, MKI67, RPS17 | KMT2A 793/4885ALDH1A1 1212/4885SMN1; SMN2 3165/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.