Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 6/20 | 0.33 |
| ▸ | JAK1 | P23458 | 6/20 | 0.33 |
| ▸ | TYK2 | P29597 | 6/20 | 0.33 |
| ▸ | JAK3 | P52333 | 6/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13455320 | 0.98 | PDE5A (0.41) | PDE5APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL17272791 | 0.92 | ALDH1A1 (0.37) | PDE5APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL22077239 | 0.75 | LMNA (0.36) | PDE5APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL6366219 | 0.66 | ADORA1 (0.43) | PDE5APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL1786994 | 0.66 | PRMT5 (0.48) | ALDH1A1LMNAPOLBCYP2C9MAPT | |
| SCHEMBL1790181 | 0.65 | PRMT5 (0.47) | ALDH1A1LMNAPOLBCYP2C9KDM4E | |
| SCHEMBL17383088 | 0.64 | MAPT (0.41) | ALDH1A1POLBJAK2JAK1TYK2 | |
| SCHEMBL13219745 | 0.64 | TXN (0.36) | PDE5APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL16082062 | 0.63 | ADORA2A (0.38) | ALDH1A1LMNAPOLBHPGDJAK2 | |
| SCHEMBL1786583 | 0.62 | ATM (0.47) | ALDH1A1LMNAPOLBCYP2C9MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1644353-A1 | AMIDE-SUBSTITUTED 1,2,4-TRIAZIN-5(2H)-ONES FOR THE TREATMENT OF CHRONICALLY INFLAMMATORY DISEASES | Bayer HealthCare AG (DE) | 2006-04-12 | — | — | EP | disclosed |
| WO-2005003118-A1 | AMIDE-SUBSTITUTED 1,2,4-TRIAZIN-5(2H)-ONES FOR THE TREATMENT OF CHRONICALLY INFLAMMATORY DISEASES | BAYER HEALTHCARE AG (DE) | 2005-01-13 | — | — | WO | disclosed |