Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 1/20 | 0.41 |
| ▸ | PDE1A | P54750 | 1/20 | 0.41 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.41 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.41 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.35 |
| ▸ | DAO | P14920 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 8/20 | 0.35 |
| ▸ | JAK1 | P23458 | 8/20 | 0.35 |
| ▸ | JAK3 | P52333 | 8/20 | 0.35 |
| ▸ | TYK2 | P29597 | 7/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5763194 | 0.98 | PDE5A (0.39) | PDE5APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL17272791 | 0.90 | ALDH1A1 (0.37) | PDE5APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL22077239 | 0.74 | LMNA (0.36) | PDE5APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL1790181 | 0.67 | PRMT5 (0.47) | ALDH1A1LMNAPOLBKDM4ECYP2C9 | |
| SCHEMBL13219745 | 0.67 | TXN (0.36) | PDE5APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL6366219 | 0.65 | ADORA1 (0.43) | PDE5APDE1APDE1BPDE3BPDE1C | |
| SCHEMBL1786994 | 0.64 | PRMT5 (0.48) | ALDH1A1LMNAPOLBKDM4EHSD17B10 | |
| SCHEMBL13219743 | 0.63 | L3MBTL1 (0.49) | ALDH1A1HPGDDAOMAPT | |
| SCHEMBL17383088 | 0.63 | MAPT (0.41) | ALDH1A1POLBKDM4EDAOJAK2 | |
| SCHEMBL11072976 | 0.62 | PDE5A (0.40) | PDE5APDE1APDE1BPDE3BPDE1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7683060-B2 | Triazolotriazines as kinase inhibitors | INCYTE CORPORATION (US) | 2010-03-23 | — | — | US | disclosed |
| US-20080039457-A1 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS | INCYTE CORPORATION (US) | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039457-A1 | TRIAZOLOTRIAZINES AS KINASE INHIBITORS | MET, ERBB2, RET | PDE5A 3156/4885PDE1A 3021/4885PDE1B 2406/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.