Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | CASP2 | P42575 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | CASP8 | Q14790 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | GLS | O94925 | 6/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.30 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.30 |
| ▸ | CDK4 | P11802 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5768181 | 0.85 | KDM4E (0.33) | KDM4EMAPTMEN1KMT2ACCNE2 | |
| SCHEMBL3619675 | 0.84 | KDM4E (0.34) | KDM4EMAPT | |
| SCHEMBL5766878 | 0.82 | CCNE2 (0.42) | KDM4ECASP3NOTUMMAPTGAA | |
| SCHEMBL5766255 | 0.82 | TAS1R3 (0.34) | KDM4EMEN1KMT2A | |
| SCHEMBL5764891 | 0.81 | KDM4E (0.35) | KDM4ECASP3NOTUMMAPTCA12 | |
| SCHEMBL5766819 | 0.80 | KDM4E (0.35) | KDM4ECASP3CASP2NOTUMMAPT | |
| SCHEMBL14371336 | 0.80 | KDM4E (0.34) | KDM4ENOTUMMAPTCA12CA2 | |
| SCHEMBL5766426 | 0.79 | KDM4E (0.36) | KDM4ENOTUMMAPTCA12CA2 | |
| SCHEMBL5765490 | 0.79 | KDM4E (0.37) | KDM4ENOTUMMAPTCA12CA2 | |
| SCHEMBL5766496 | 0.79 | ALDH1A1 (0.35) | KDM4ENOTUMMAPTALDH1A1CCNE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979821-B1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2006-09-13 | — | — | EP | disclosed |
| US-6211227-B1 | SULFUR CONTAINING TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0979821-A1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-02-16 | — | — | EP | disclosed |