Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 2/20 | 0.31 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.31 |
| ▸ | CDK2 | P24941 | 2/20 | 0.31 |
| ▸ | CDK4 | P11802 | 1/20 | 0.31 |
| ▸ | CCND1 | P24385 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | PTPRC | P08575 | 1/20 | 0.30 |
| ▸ | PTPN13 | Q12923 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5765322 | 0.85 | ALDH1A1 (0.42) | KDM4EMAPTKMT2AMEN1GLA | |
| SCHEMBL5766878 | 0.85 | CCNE2 (0.42) | KDM4EMAPTCCNE2CCNE1CDK2 | |
| SCHEMBL3619675 | 0.85 | KDM4E (0.34) | KDM4EMAPT | |
| SCHEMBL5764009 | 0.85 | KDM4E (0.34) | KDM4EMAPTKMT2AMEN1CCNE2 | |
| SCHEMBL5766255 | 0.82 | TAS1R3 (0.34) | KDM4EKMT2AMEN1 | |
| SCHEMBL5766496 | 0.82 | ALDH1A1 (0.35) | KDM4EMAPTCCNE2CCNE1CDK2 | |
| SCHEMBL5765490 | 0.82 | KDM4E (0.37) | KDM4EMAPTKMT2ACCNE2CCNE1 | |
| SCHEMBL5764891 | 0.82 | KDM4E (0.35) | KDM4EMAPTCCNE2CCNE1CDK2 | |
| SCHEMBL5766199 | 0.81 | ALDH1A1 (0.42) | KDM4EMAPTKMT2AMEN1HPGD | |
| SCHEMBL5679654 | 0.81 | HDAC3 (0.35) | KDM4EMAPTCCNE2CCNE1CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0979821-B1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO KK (JP) | 2006-09-13 | — | — | EP | disclosed |
| US-6211227-B1 | SULFUR CONTAINING TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2001-04-03 | — | — | US | disclosed |
| EP-0979821-A1 | TRICYCLIC COMPOUNDS | KYOWA HAKKO KOGYO CO., LTD. (JP) | 2000-02-16 | — | — | EP | disclosed |