Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | NT5E | P21589 | 7/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 5/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.37 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.37 |
| ▸ | CDK7 | P50613 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5765833 | 0.83 | HSD11B1 (0.41) | KDM4ENT5EPIM1MAPK14RAB9A | |
| SCHEMBL5763633 | 0.81 | MAPK14 (0.50) | MAPK14 | |
| SCHEMBL9844320 | 0.73 | KDM4E (0.49) | KDM4EHSD17B10NT5EPIM1MAPK14 | |
| SCHEMBL30502803 | 0.72 | ACP3 (0.55) | EPHX1 | |
| SCHEMBL3859898 | 0.72 | ACP3 (0.55) | EPHX1 | |
| SCHEMBL477409 | 0.72 | ACP3 (0.55) | EPHX1 | |
| SCHEMBL5766533 | 0.72 | MEN1 (0.45) | KDM4EHSD17B10DPP4NT5EPIM1 | |
| SCHEMBL822105 | 0.71 | ACHE (0.52) | EPHX1 | |
| SCHEMBL14280077 | 0.70 | HSD11B1 (0.43) | KDM4EHSD17B10MAPK14RAB9A | |
| SCHEMBL32665199 | 0.70 | KDM4E (0.50) | KDM4EHSD17B10DPP4NT5EPIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| US-7321040-B2 | Triazolo-pyridines as anti-inflammatory compounds | PFIZER INC. (US) | 2008-01-22 | — | — | US | disclosed |
| EP-1601672-B1 | TRIAZOLO-PYRIDINES AS ANTI-INFLAMMATORY COMPOUNDS | PFIZER PROD INC (US) | 2006-07-26 | — | — | EP | disclosed |