Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.35 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5776847 | 0.89 | MDM2 (0.39) | ALDH1A1L3MBTL1MAPTHTTTSHR | |
| Trifluoroacetic Acid SCHEMBL5776834 | 0.85 | HTT (0.46) | MAPTHTTLMNASMN1; SMN2ALOX5 | |
| Trifluoroacetic Acid SCHEMBL5772964 | 0.85 | TSHR (0.45) | KDM4ETSHRCYP3A4ALOX5MEN1 | |
| Trifluoroacetic Acid SCHEMBL5776822 | 0.83 | DPP8 (0.50) | ALDH1A1MAPTHTTTSHRALOX5 | |
| Trifluoroacetic Acid SCHEMBL5777433 | 0.83 | GFER (0.53) | ALDH1A1HSD17B10GAAMAPTLMNA | |
| Trifluoroacetic Acid SCHEMBL5770010 | 0.82 | HTR1A (0.49) | KDM4EALDH1A1HSD17B10L3MBTL1MAPT | |
| SCHEMBL5907061 | 0.81 | HTR2A (0.39) | MAPTHTTLMNASMN1; SMN2ALOX5 | |
| Trifluoroacetic Acid SCHEMBL5773395 | 0.81 | LMNA (0.48) | KDM4EALDH1A1GAAMAPTLMNA | |
| Trifluoroacetic Acid SCHEMBL5773386 | 0.81 | LMNA (0.48) | KDM4EALDH1A1GAAMAPTLMNA | |
| Trifluoroacetic Acid SCHEMBL5772610 | 0.81 | GFER (0.53) | MAPTLMNATSHRMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | KDM4E 3953/4885ALDH1A1 1045/4885ALOX15 577/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | KDM4E 3347/4885ALDH1A1 682/4885ALOX15 800/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.