Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.40 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.40 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5770703 | 1.00 | TSHR (0.40) | TSHRGABRA5GABRB2GABRPGABRD | |
| SCHEMBL21001913 | 0.85 | TSHR (0.44) | TSHRGABRA5GABRB2GABRPGABRD | |
| Hydrochloric Acid SCHEMBL422775 | 0.83 | TSHR (0.43) | TSHRGABRA5GABRB2GABRPGABRD | |
| Hydrochloric Acid SCHEMBL422774 | 0.83 | TSHR (0.43) | TSHRGABRA5GABRB2GABRPGABRD | |
| SCHEMBL8269104 | 0.79 | HTT (0.42) | TSHRPTPN1POLBTP53EGLN1 | |
| SCHEMBL11397426 | 0.73 | SLC6A1 (0.39) | TSHRGABRA5GABRB2GABRPGABRD | |
| SCHEMBL3260263 | 0.71 | TSHR (0.38) | TSHRGABRA5GABRB2GABRPGABRD | |
| SCHEMBL3260266 | 0.71 | TSHR (0.38) | TSHRGABRA5GABRB2GABRPGABRD | |
| SCHEMBL12535933 | 0.69 | GABRA1 (0.35) | TSHRGABRA5GABRB2GABRPGABRD | |
| Acetic Acid SCHEMBL27798837 | 0.69 | GABRP (0.38) | TSHRGABRA5GABRB2GABRPGABRD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7053214-B2 | β-sheet mimetics and composition and methods relating thereto | MYRIAD GENETICS, INC. (US) | 2006-05-30 | — | — | US | disclosed |
| US-20060084653-A1 | Beta-sheet mimetics and composition and methods relating thereto | MYRIAD GENETICS, INCORPORATED (US) | 2006-04-20 | — | — | US | disclosed |
| EP-1482941-A4 | BETA-SHEET MIMETICS AND COMPOSITION AND METHODS RELATING THERETO | MYRIAD GENETICS INC (US) | 2006-04-12 | — | — | EP | disclosed |
| EP-1482941-A1 | BETA-SHEET MIMETICS AND COMPOSITION AND METHODS RELATING THERETO | Myriad Pharmaceuticals, Inc. (US) | 2004-12-08 | — | — | EP | disclosed |
| US-20040014763-A1 | beta-sheet mimetics and composition and methods relating thereto | MYRIAD PHARMACEUTICALS, INC. (US) | 2004-01-22 | — | — | US | disclosed |
| US-20040014763-A1 | beta-sheet mimetics and composition and methods relating thereto | MYRIAD PHARMACEUTICALS, INC. (US) | 2004-01-22 | — | — | US | disclosed |
| US-20040014763-A1 | beta-sheet mimetics and composition and methods relating thereto | MYRIAD PHARMACEUTICALS, INC. (US) | 2004-01-22 | — | — | US | disclosed |
| WO-2003068237-A1 | BETA-SHEET MIMETICS AND COMPOSITION AND METHODS RELATING THERETO | MYRIAD GENETICS, INC. (US) | 2003-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040014763-A1 | beta-sheet mimetics and composition and methods relating thereto | TPSAB1, TPSB2, TPSD1 | TSHR 2505/4885GABRA5 2470/4885GABRB2 1605/4885 |
| US-20060084653-A1 | Beta-sheet mimetics and composition and methods relating thereto | TPSAB1, TPSB2, TPSD1 | TSHR 2101/4885GABRA5 2302/4885GABRB2 1025/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.