Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 7/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 4/20 | 0.42 |
| ▸ | DHODH | Q02127 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.38 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6024132 | 0.86 | PTGS2 (0.61) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL577295 | 0.76 | PTGS2 (0.53) | PTGS2PTGS1ABCB11PPARGNR1I3 | |
| SCHEMBL457991 | 0.73 | CXCL8 (0.51) | PTGS2PTGS1ABCB11NR1I3GAA | |
| SCHEMBL9618521 | 0.72 | CXCL8 (0.50) | PTGS2PTGS1ABCB11NR1I3GAA | |
| SCHEMBL1961600 | 0.72 | CXCL8 (0.50) | PTGS2PTGS1ABCB11NR1I3GAA | |
| Potassium SCHEMBL8053105 | 0.72 | CXCL8 (0.50) | PTGS2PTGS1ABCB11NR1I3GAA | |
| SCHEMBL9618518 | 0.72 | CXCL8 (0.50) | PTGS2PTGS1ABCB11NR1I3GAA | |
| SCHEMBL29598223 | 0.72 | CXCL8 (0.50) | PTGS2PTGS1ABCB11NR1I3GAA | |
| Rubidium SCHEMBL9618522 | 0.72 | CXCL8 (0.50) | PTGS2PTGS1ABCB11NR1I3GAA | |
| SCHEMBL8053100 | 0.72 | CXCL8 (0.50) | PTGS2PTGS1ABCB11NR1I3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2418200-A1 | PHTHALIMIDE DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND/OR TNF- MODULATORS, METHOD FOR PRODUCING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF FOR THE TREATMENT OF INFLAMMATORY DISEASES | EMS S. A. (BR) | 2012-02-15 | — | — | EP | disclosed |