Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.45 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.45 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.44 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | FABP3 | P05413 | 1/20 | 0.41 |
| ▸ | FABP4 | P15090 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CXCL8 | P10145 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL457991 | 0.82 | CXCL8 (0.51) | PTGS2ABCB11PTGS1NR1I3CLCN2 | |
| SCHEMBL29598223 | 0.81 | CXCL8 (0.50) | PTGS2ABCB11PTGS1NR1I3CLCN2 | |
| Rubidium SCHEMBL9618522 | 0.81 | CXCL8 (0.50) | PTGS2ABCB11PTGS1NR1I3CLCN2 | |
| SCHEMBL8053100 | 0.81 | CXCL8 (0.50) | PTGS2ABCB11PTGS1NR1I3CLCN2 | |
| Potassium SCHEMBL8053105 | 0.81 | CXCL8 (0.50) | PTGS2ABCB11PTGS1NR1I3CLCN2 | |
| SCHEMBL9618521 | 0.81 | CXCL8 (0.50) | PTGS2ABCB11PTGS1NR1I3CLCN2 | |
| SCHEMBL9618518 | 0.81 | CXCL8 (0.50) | PTGS2ABCB11PTGS1NR1I3CLCN2 | |
| SCHEMBL1961600 | 0.81 | CXCL8 (0.50) | PTGS2ABCB11PTGS1NR1I3CLCN2 | |
| SCHEMBL6024132 | 0.81 | PTGS2 (0.61) | PTGS2ABCB11PTGS1PPARGNR1I3 | |
| SCHEMBL9790062 | 0.80 | GHSR (0.41) | PTGS2ABCB11PTGS1NR1I3LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2418200-A1 | PHTHALIMIDE DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND/OR TNF- MODULATORS, METHOD FOR PRODUCING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF FOR THE TREATMENT OF INFLAMMATORY DISEASES | EMS S. A. (BR) | 2012-02-15 | — | — | EP | disclosed |