Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | POLQ | O75417 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 8/20 | 0.36 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.34 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5771067 | 0.92 | HDAC8 (0.35) | GSK3BHDAC8SLC22A12 | |
| SCHEMBL5772670 | 0.90 | POLQ (0.40) | GSK3BHDAC1HDAC2HDAC8POLQ | |
| SCHEMBL5775722 | 0.85 | GSK3B (0.41) | GSK3BHDAC1HDAC2HDAC8TRPV1 | |
| SCHEMBL5772985 | 0.85 | GSK3B (0.41) | GSK3BHDAC1HDAC2HDAC8TRPV1 | |
| SCHEMBL5776431 | 0.83 | MET (0.37) | HDAC1HDAC2HDAC8NPC1RAB9A | |
| SCHEMBL5776662 | 0.80 | TRPV1 (0.37) | HDAC1HDAC2HDAC8TRPV1SMN1; SMN2 | |
| SCHEMBL5774478 | 0.79 | HIF1A (0.42) | S1PR1SMN1; SMN2CYP3A4HTR1AHTR2A | |
| SCHEMBL5773874 | 0.79 | MAPT (0.42) | SMN1; SMN2CYP3A4CYP2C19 | |
| SCHEMBL5774056 | 0.78 | TRPV1 (0.38) | HDAC1HDAC2HDAC8TRPV1 | |
| SCHEMBL5772669 | 0.78 | NOS1 (0.42) | GSK3BSMN1; SMN2NPC1TP53CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | GSK3B 1517/4885HDAC1 353/4885HDAC2 449/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | GSK3B 2013/4885HDAC1 184/4885HDAC2 391/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.