SCHEMBL5772424

SCHEMBL5772424

CCc1c(Cc2[nH]c(Cc3[nH]c(C(=O)O)c(C)c3CC)c(CC)c2CC)[nH]c(C(=O)O)c1C

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.49
NPSR1 Q6W5P4 3/20 0.42
MEN1 O00255 2/20 0.42
GAA P10253 2/20 0.42
TSHR P16473 2/20 0.42
KMT2A Q03164 2/20 0.42
ALOX12 P18054 1/20 0.42
CYP1A2 P05177 5/20 0.36
CYP2C9 P11712 3/20 0.36
RAB9A P51151 2/20 0.36
MAPT P10636 2/20 0.36
STAT1 P42224 1/20 0.36
CYP2D6 P10635 1/20 0.36
HCAR2 Q8TDS4 1/20 0.36
CYP2C19 P33261 3/20 0.36
PRNP P04156 1/20 0.36
PPARG P37231 1/20 0.36
HIF1A Q16665 1/20 0.36
RXFP1 Q9HBX9 1/20 0.36
NR2E3 Q9Y5X4 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13228906 0.89 NPSR1 (0.44) LMNANPSR1MEN1GAATSHR
SCHEMBL7668283 0.88 NPSR1 (0.43) LMNANPSR1MEN1GAATSHR
SCHEMBL9423133 0.85 TSHR (0.47) LMNANPSR1MEN1GAATSHR
SCHEMBL9079647 0.82 LMNA (0.40) LMNANPSR1MEN1GAATSHR
SCHEMBL18210830 0.82 HSD17B10 (0.58) LMNANPSR1MEN1GAATSHR
SCHEMBL7698795 0.82 NPSR1 (0.44) LMNANPSR1MEN1GAATSHR
SCHEMBL8632439 0.81 NPSR1 (0.65) LMNANPSR1MEN1GAATSHR
SCHEMBL8874894 0.80 RAB9A (0.42) NPSR1MEN1GAATSHRKMT2A
SCHEMBL8632437 0.79 LMNA (0.44) LMNANPSR1MEN1GAATSHR
SCHEMBL8185405 0.78 LMNA (0.37) LMNANPSR1MEN1GAATSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5302714-A Sapphyrins, derivatives and syntheses BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1994-04-12 US claimed
EP-0515395-A1 SAPPHYRINS, DERIVATIVES AND SYNTHESIS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1992-12-02 EP claimed
WO-1991009861-A1 SAPPHYRINS, DERIVATIVES AND SYNTHESIS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1991-07-11 WO claimed
EP-3283493-B1 TEXAPHYRIN-PHOSPHOLIPID CONJUGATES AND METHODS OF PREPARING SAME UNIV HEALTH NETWORK UHN (CA) 2020-11-18 EP disclosed
US-10729792-B2 Texaphyrin-phospholipid conjugates and methods of preparing same UNIVERSITY HEALTH NETWORK (CA) 2020-08-04 US disclosed
US-20180104364-A1 TEXAPHYRIN-PHOSPHOLIPID CONJUGATES AND METHODS OF PREPARING SAME UNIVERSITY HEALTH NETWORK (CA) 2018-04-19 US disclosed
US-20180104364-A1 TEXAPHYRIN-PHOSPHOLIPID CONJUGATES AND METHODS OF PREPARING SAME UNIVERSITY HEALTH NETWORK (CA) 2018-04-19 US disclosed
WO-2016165006-A1 TEXAPHYRIN-PHOSPHOLIPID CONJUGATES AND METHODS OF PREPARING SAME UNIVERSITY HEALTH NETWORK (CA) 2016-10-20 WO disclosed
EP-0885228-B1 MESO-SUBSTITUTED TRIPYRRANE COMPOUNDS, COMPOSITIONS, AND METHODS FOR MAKING AND USING THE SAME UNIV BRITISH COLUMBIA (CA) 2006-05-31 EP disclosed
US-6022981-A KEY INTERMEDIATES IN SYNTHESIZING 5,10-DISUBSTITUTED PORPHYRIN COMPOUNDS OR OTHER 5,10-DISUBSTITUTED POLYPYRROLIC MACROCYCLES. THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2000-02-08 US disclosed
US-5919923-A REACTING ALDEHYDE OR ACETAL WITH STOICHIOMETRIC EXCESS OF PYRROLE IN PRESENCE OF ACID CATALYST, REMOVING SOLVENT BY EVAPORATION TO FORM RESIDUE, REMOVING HIGH MOLECULAR WEIGHT BY-PRODUCTS TO LEAVE DESIRED TRIPYRRANE BRITISH COLUMBIA, UNIVERSITY OF, THE (CA) 1999-07-06 US disclosed
US-5883246-A CYCLIZATION OF POLYPYRROLES AND OXIDATION TO FORM POLYPYRROLE MACROCYCLE QLT PHOTOTHERAPEUTICS, INC. (CA) 1999-03-16 US disclosed
US-5302714-A Sapphyrins, derivatives and syntheses BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1994-04-12 US disclosed
EP-0515395-A1 SAPPHYRINS, DERIVATIVES AND SYNTHESIS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1992-12-02 EP disclosed
US-5159065-A SAPPHYRINS, DERIVATIVES AND SYNTHESES BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1992-10-27 US disclosed
WO-1991009861-A1 SAPPHYRINS, DERIVATIVES AND SYNTHESIS BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) 1991-07-11 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20180104364-A1 TEXAPHYRIN-PHOSPHOLIPID CONJUGATES AND METHODS OF PREPARING SAME PLTP, PHOSPHO1, TEX13A LMNA 781/4885NPSR1 3518/4885MEN1 208/4885
US-10729792-B2 Texaphyrin-phospholipid conjugates and methods of preparing same PLTP, PHOSPHO1, TEX13A LMNA 781/4885NPSR1 3518/4885MEN1 208/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.