Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDE | P14735 | 10/20 | 0.49 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5773631 | 0.92 | POLB (0.48) | IDEHDAC4HDAC6NPC1SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5775717 | 0.82 | GSK3B (0.44) | GSK3BCYP1A2CYP2D6CYP2C9CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL5774050 | 0.80 | TRPV1 (0.43) | HDAC6 | |
| Trifluoroacetic Acid SCHEMBL5772978 | 0.80 | GSK3B (0.52) | HDAC6GSK3BCYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5772669 | 0.79 | NOS1 (0.42) | HDAC4HDAC6GSK3AGSK3BCYP1A2 | |
| Trifluoroacetic Acid SCHEMBL5773866 | 0.79 | ALDH1A1 (0.48) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 | |
| Trifluoroacetic Acid SCHEMBL5772750 | 0.79 | MAPT (0.40) | SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5776657 | 0.79 | MAPT (0.42) | HDAC4HDAC6SMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5775554 | 0.79 | HDAC4 (0.43) | HDAC4HDAC6CYP1A2CYP2D6CYP2C9 | |
| Trifluoroacetic Acid SCHEMBL5774863 | 0.79 | HSD17B10 (0.43) | CYP1A2CYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | IDE 26/4885HDAC4 434/4885HDAC6 1324/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | IDE 14/4885HDAC4 497/4885HDAC6 1224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.