Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.36 |
| ▸ | CYP46A1 | Q9Y6A2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5776131 | 0.84 | LMNA (0.42) | GRIN2BKCNH2LMNAKMT2AMEN1 | |
| Trifluoroacetic Acid SCHEMBL5776922 | 0.80 | MCHR1 (0.43) | GRIN2BKCNH2LMNAKMT2AMEN1 | |
| SCHEMBL5775136 | 0.79 | BACE1 (0.47) | BACE1GRIN2BLMNAKMT2AMEN1 | |
| SCHEMBL5777123 | 0.78 | HPGD (0.50) | LMNAALDH1A1KMT2AMEN1NPC1 | |
| Trifluoroacetic Acid SCHEMBL5774584 | 0.77 | MEN1 (0.44) | KCNH2KMT2AMEN1 | |
| Trifluoroacetic Acid SCHEMBL5773114 | 0.75 | LMNA (0.41) | BACE1KCNH2LMNAKMT2AL3MBTL1 | |
| SCHEMBL5769884 | 0.75 | NPC1 (0.54) | LMNAMAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL5773998 | 0.75 | FFAR1 (0.46) | LMNAMAPTALDH1A1L3MBTL1 | |
| SCHEMBL5775388 | 0.75 | POLB (0.37) | LMNAALDH1A1L3MBTL1RAB9A | |
| SCHEMBL5773468 | 0.74 | LMNA (0.46) | LMNAMAPTALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | BACE1 1040/4885GRIN2B 2007/4885KCNH2 1149/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | BACE1 619/4885GRIN2B 2374/4885KCNH2 834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.