Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.46 |
| ▸ | RXRB | P28702 | 8/20 | 0.46 |
| ▸ | RXRG | P48443 | 8/20 | 0.46 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | FABP4 | P15090 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774355 | 0.88 | FABP4 (0.47) | RXRARXRBRXRGPTGS2PTGS1 | |
| SCHEMBL5775162 | 0.76 | FFAR4 (0.45) | GABRA1 | |
| SCHEMBL10746091 | 0.73 | PTGS2 (0.51) | ENPP2PTGS2GABRA1GABRA2PTGS1 | |
| SCHEMBL5774661 | 0.73 | SIGMAR1 (0.56) | — | |
| SCHEMBL5772957 | 0.73 | POLB (0.55) | RXRARXRBRXRGMAPT | |
| SCHEMBL11593125 | 0.72 | PTGS2 (0.54) | ENPP2NR1H4PTGS2GABRA1GABRA2 | |
| SCHEMBL1712324 | 0.71 | NR1H4 (0.43) | ENPP2NR1H4GABRA1GABRA2 | |
| SCHEMBL11665630 | 0.71 | PTGS2 (0.50) | ENPP2NR1H4PTGS2GABRA1GABRA2 | |
| SCHEMBL11596013 | 0.71 | PTGS2 (0.49) | ENPP2PTGS2GABRA1GABRA2PTGS1 | |
| SCHEMBL4878309 | 0.71 | PTGS2 (0.49) | ENPP2PTGS2GABRA1GABRA2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885883-B1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | MITSUBISHI PHARMA CORP (JP) | 2006-11-02 | — | — | EP | disclosed |
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |