Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.39 |
| ▸ | GPR183 | P32249 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.34 |
| ▸ | CDK8 | P49336 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5776834 | 0.91 | HTT (0.46) | POLBHDAC4HDAC6SMN1; SMN2HTT | |
| Trifluoroacetic Acid SCHEMBL5771806 | 0.84 | POLB (0.47) | POLBHDAC4HDAC6HPGDALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5773114 | 0.82 | LMNA (0.41) | POLBPPARAHDAC4HDAC6LMNA | |
| Trifluoroacetic Acid SCHEMBL5776847 | 0.82 | MDM2 (0.39) | HTTMAPTTSHRALDH1A1KMT2A | |
| Trifluoroacetic Acid SCHEMBL5772964 | 0.81 | TSHR (0.45) | TSHRKMT2A | |
| Trifluoroacetic Acid SCHEMBL5777433 | 0.80 | GFER (0.53) | POLBLMNAHPGDMAPTTSHR | |
| SCHEMBL5773586 | 0.79 | MAPT (0.43) | POLBPPARAGPR183SMN1; SMN2HTT | |
| Trifluoroacetic Acid SCHEMBL5772610 | 0.79 | GFER (0.53) | POLBLMNAMAPTTSHRNPC1 | |
| Trifluoroacetic Acid SCHEMBL5776822 | 0.77 | DPP8 (0.50) | HTTMAPTTSHRALDH1A1KMT2A | |
| Trifluoroacetic Acid SCHEMBL5776691 | 0.77 | GRM5 (0.48) | POLBSMN1; SMN2HTTMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | POLB 3996/4885PPARA 602/4885HDAC4 434/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | POLB 3909/4885PPARA 247/4885HDAC4 497/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.