Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.48 |
| ▸ | SLC6A7 | Q99884 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | CETP | P11597 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | HTR7 | P34969 | 1/20 | 0.41 |
| ▸ | ME2 | P23368 | 1/20 | 0.41 |
| ▸ | ME1 | P48163 | 1/20 | 0.41 |
| ▸ | ME3 | Q16798 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5774748 | 0.90 | ALDH1A1 (0.53) | GRM5L3MBTL1KDM4EHTR7ME2 | |
| Trifluoroacetic Acid SCHEMBL5772610 | 0.89 | GFER (0.53) | GFERTSHRPOLBNPC1MAPT | |
| Trifluoroacetic Acid SCHEMBL5777433 | 0.89 | GFER (0.53) | GFERALDH1A1TSHRPOLBNPC1 | |
| Trifluoroacetic Acid SCHEMBL5775321 | 0.86 | KMT2A (0.53) | L3MBTL1GFERALDH1A1TSHRSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5776834 | 0.86 | HTT (0.46) | GFERHTTHTR7ME2ME1 | |
| Trifluoroacetic Acid SCHEMBL5776836 | 0.86 | PARP1 (0.44) | L3MBTL1GFERHTR7TSHRGAA | |
| Trifluoroacetic Acid SCHEMBL5775195 | 0.85 | ATM (0.49) | L3MBTL1GFERMAPT | |
| Trifluoroacetic Acid SCHEMBL5774077 | 0.85 | POLB (0.51) | GFERHTR7ALDH1A1POLBHTR1A | |
| Trifluoroacetic Acid SCHEMBL5776129 | 0.84 | MEN1 (0.50) | GFERKDM4EHTTHTR7ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5776847 | 0.84 | MDM2 (0.39) | L3MBTL1GFERHTTHTR7ME2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | GRM5 2777/4885SLC6A7 1252/4885L3MBTL1 2718/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | GRM5 2662/4885SLC6A7 1533/4885L3MBTL1 1898/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.