Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.59 |
| ▸ | DRD2 | P14416 | 5/20 | 0.53 |
| ▸ | DCTPP1 | Q9H773 | 2/20 | 0.52 |
| ▸ | TNKS | O95271 | 1/20 | 0.52 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 6/20 | 0.49 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | DRD4 | P21917 | 2/20 | 0.48 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 2/20 | 0.48 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.48 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.48 |
| ▸ | HRH2 | P25021 | 1/20 | 0.48 |
| ▸ | HTR1B | P28222 | 1/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.48 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.48 |
| ▸ | HTR2B | P41595 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776645 | 0.85 | KCNH2 (0.57) | KCNH2HTR1AHTR7ADRA2AADRA1A | |
| SCHEMBL5772832 | 0.85 | SIGMAR1 (0.53) | KCNH2DRD2TNKSTNKS2HTR1A | |
| SCHEMBL5772457 | 0.84 | SIGMAR1 (0.52) | KCNH2DRD2TNKSTNKS2HTR1A | |
| SCHEMBL5776276 | 0.83 | SIGMAR1 (0.58) | DRD2HTR1AHTR7DRD4HTR2A | |
| SCHEMBL5774848 | 0.83 | HTR7 (0.56) | DRD2HTR1AHTR7HTR2ASIGMAR1 | |
| SCHEMBL5776684 | 0.82 | SIGMAR1 (0.53) | KCNH2DRD2HTR1AHTR7DRD4 | |
| SCHEMBL5775439 | 0.81 | MAPT (0.45) | KCNH2DRD2HTR7DRD4HRH1 | |
| SCHEMBL5777048 | 0.80 | DRD2 (0.56) | DRD2HTR1AHTR7DRD4HTR2A | |
| SCHEMBL5774841 | 0.80 | HTR7 (0.42) | DRD2HTR1AHTR7DRD4HTR2A | |
| SCHEMBL5775029 | 0.80 | MAPT (0.44) | KCNH2DRD2HTR7DRD4HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885883-B1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | MITSUBISHI PHARMA CORP (JP) | 2006-11-02 | — | — | EP | disclosed |
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |