Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 3/20 | 0.57 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.57 |
| ▸ | HTR1A | P08908 | 2/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.54 |
| ▸ | PARP1 | P09874 | 1/20 | 0.50 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5772229 | 0.87 | SIGMAR1 (0.52) | SIGMAR1HTR1ADRD1SLC6A4DRD3 | |
| SCHEMBL5772832 | 0.87 | SIGMAR1 (0.53) | KCNH2SIGMAR1HTR1ADRD3PARP1 | |
| SCHEMBL5774841 | 0.86 | HTR7 (0.42) | SIGMAR1HTR1ADRD1SLC6A4DRD3 | |
| SCHEMBL5776696 | 0.86 | SIGMAR1 (0.51) | SIGMAR1HTR1ADRD1SLC6A4DRD3 | |
| SCHEMBL5772457 | 0.85 | SIGMAR1 (0.52) | KCNH2SIGMAR1HTR1ADRD3PARP1 | |
| SCHEMBL5773811 | 0.85 | KCNH2 (0.59) | KCNH2SIGMAR1HTR1AADRA2ADRD1 | |
| SCHEMBL5774848 | 0.85 | HTR7 (0.56) | SIGMAR1HTR1ADRD1DRD3HTR7 | |
| SCHEMBL5776684 | 0.84 | SIGMAR1 (0.53) | KCNH2SIGMAR1HTR1ADRD3PARP1 | |
| Hydrochloric Acid SCHEMBL5770744 | 0.84 | SIGMAR1 (0.51) | SIGMAR1HTR1ADRD1SLC6A4DRD3 | |
| SCHEMBL5773754 | 0.83 | ADRA1B (0.49) | KCNH2HTR1ACHRM1ADRA1ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0885883-B1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | MITSUBISHI PHARMA CORP (JP) | 2006-11-02 | — | — | EP | disclosed |
| US-6187774-B1 | N-PIPERAZINYLALKYLINDAZOLE DERIVATIVES; PSYCHOLOGICAL DISORDERS, SCHIZOPHRENIA; SIDE EFFECT REDUCTION | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0885883-A1 | FUSED HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL APPLICATIONS THEREOF | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1998-12-23 | — | — | EP | disclosed |