Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 12/20 | 0.56 |
| ▸ | RXRB | P28702 | 12/20 | 0.56 |
| ▸ | RXRG | P48443 | 8/20 | 0.56 |
| ▸ | NR4A2 | P43354 | 5/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.56 |
| ▸ | C5 | P01031 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.56 |
| ▸ | DRD2 | P14416 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.56 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.56 |
| ▸ | HTR2A | P28223 | 1/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22769587 | 0.85 | PTGS1 (0.48) | RXRARXRBRXRGNR4A2PTGS1 | |
| SCHEMBL5773335 | 0.84 | FFAR4 (0.49) | RXRARXRBRXRGNR4A2PTGS1 | |
| SCHEMBL2279660 | 0.84 | NR4A2 (0.54) | RXRARXRBRXRGNR4A2PTGS1 | |
| SCHEMBL5773143 | 0.83 | FFAR4 (0.51) | RXRARXRBRXRGNR4A2PTGS1 | |
| SCHEMBL22769588 | 0.80 | HDAC1 (0.54) | RXRARXRBRXRGNR4A2PTGS1 | |
| SCHEMBL31526337 | 0.78 | PTGS1 (0.47) | PTGS1PTGS2FFAR4 | |
| SCHEMBL22769599 | 0.76 | PTGS1 (0.50) | NR4A2PTGS1KDM4ENR4A1MAPK1 | |
| SCHEMBL5729762 | 0.76 | NR4A2 (0.45) | NR4A2PTGS1KDM4ELMNAFFAR4 | |
| SCHEMBL6170053 | 0.75 | PTGS2 (0.59) | RXRARXRBRXRGNR4A2PTGS1 | |
| SCHEMBL12406914 | 0.75 | PTGS1 (0.59) | NR4A2PTGS1KDM4ELMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | RXRA 445/4885RXRB 494/4885RXRG 503/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | RXRA 462/4885RXRB 550/4885RXRG 628/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.