Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 8/20 | 0.54 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.54 |
| ▸ | NR4A3 | Q92570 | 2/20 | 0.54 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.51 |
| ▸ | PPARD | Q03181 | 2/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | RXRA | P19793 | 3/20 | 0.44 |
| ▸ | RXRB | P28702 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | RXRG | P48443 | 2/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | C5 | P01031 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22769599 | 0.84 | PTGS1 (0.50) | NR4A2NR4A1NR4A3PTGS1PTPN1 | |
| SCHEMBL5774112 | 0.84 | RXRA (0.56) | NR4A2NR4A1NR4A3PTGS1PPARD | |
| SCHEMBL12406914 | 0.83 | PTGS1 (0.59) | NR4A2NR4A1NR4A3PTGS1PPARD | |
| SCHEMBL11897018 | 0.82 | SMN1; SMN2 (0.49) | NR4A2NR4A1NR4A3PTGS1PTPN1 | |
| SCHEMBL27495332 | 0.82 | ALDH1A1 (0.59) | PTGS1KDM4ETSHRPTGS2ALDH1A1 | |
| SCHEMBL2278944 | 0.82 | PPARD (0.42) | NR4A2NR4A1NR4A3PTGS1PPARD | |
| SCHEMBL31526337 | 0.81 | PTGS1 (0.47) | PTGS1PTPN1FFAR4PTGS2ALDH1A1 | |
| SCHEMBL27749854 | 0.80 | PTGS2 (0.58) | NR4A2NR4A1NR4A3PTGS1PPARD | |
| SCHEMBL22769587 | 0.76 | PTGS1 (0.48) | NR4A2NR4A1NR4A3PTGS1FFAR4 | |
| SCHEMBL22769588 | 0.74 | HDAC1 (0.54) | NR4A2PTGS1FFAR4RXRARXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7989450-B2 | Functionalized diarylisoxazoles inhibitors of ciclooxygenase | UNIVERSITA' DEGLI STUDI DI BARI (IT) | 2011-08-02 | — | — | US | disclosed |
| US-20090181970-A1 | Functionalized diarylisoxazoles inhibitors of ciclooxygenase | UNIVERSITA' DEGLI STUDI DI BARI (IT) | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181970-A1 | Functionalized diarylisoxazoles inhibitors of ciclooxygenase | PTGIS, ALOX5, ALOX15 | NR4A2 3206/4885NR4A1 2510/4885NR4A3 2583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.