Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5777111 | 0.95 | CD274 (0.49) | TSHRUSP2LMNAPOLBSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5773355 | 0.91 | TSHR (0.50) | TSHRUSP2LMNAPOLBSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5775671 | 0.87 | TSHR (0.41) | TSHRUSP2LMNAPOLBSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5773422 | 0.82 | HSD17B10 (0.43) | TSHRUSP2LMNASMN1; SMN2KDM4E | |
| Trifluoroacetic Acid SCHEMBL5773631 | 0.82 | POLB (0.48) | LMNAPOLBSMN1; SMN2KMT2AMEN1 | |
| Trifluoroacetic Acid SCHEMBL5777271 | 0.80 | GAA (0.37) | TSHRUSP2LMNAPOLBSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5774893 | 0.80 | GAA (0.47) | TSHRUSP2LMNASMN1; SMN2KMT2A | |
| Trifluoroacetic Acid SCHEMBL5777437 | 0.79 | ACKR3 (0.41) | TSHRUSP2LMNASMN1; SMN2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5774844 | 0.79 | HDAC4 (0.40) | LMNAKMT2AMEN1GAAALDH1A1 | |
| SCHEMBL5774298 | 0.79 | TSHR (0.42) | TSHRUSP2LMNASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | TSHR 534/4885USP2 3981/4885LMNA 2770/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | TSHR 583/4885USP2 3792/4885LMNA 2605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.