Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5774863 | 0.93 | HSD17B10 (0.43) | HSD17B10KDM4ETSHRHRH3HTT | |
| Trifluoroacetic Acid SCHEMBL5773355 | 0.84 | TSHR (0.50) | KDM4ETSHRHTTSMN1; SMN2ALDH1A1 | |
| Trifluoroacetic Acid SCHEMBL5773774 | 0.83 | TSHR (0.41) | KDM4ESLC2A1TSHRHRH3HTT | |
| Trifluoroacetic Acid SCHEMBL5775671 | 0.83 | TSHR (0.41) | KDM4ESLC2A1TSHRHRH3HTT | |
| Trifluoroacetic Acid SCHEMBL5774292 | 0.82 | TSHR (0.50) | KDM4ETSHRHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL5773426 | 0.81 | ACHE (0.41) | HSD17B10KDM4ESLC2A1CACNA1GTSHR | |
| Trifluoroacetic Acid SCHEMBL5777111 | 0.79 | CD274 (0.49) | HSD17B10TSHRSMN1; SMN2USP2LMNA | |
| Trifluoroacetic Acid SCHEMBL5773631 | 0.78 | POLB (0.48) | HTTSMN1; SMN2LMNAKMT2AMEN1 | |
| Trifluoroacetic Acid SCHEMBL5774893 | 0.78 | GAA (0.47) | TSHRHTTSMN1; SMN2ALDH1A1USP2 | |
| Trifluoroacetic Acid SCHEMBL5777437 | 0.77 | ACKR3 (0.41) | TSHRHTTSMN1; SMN2ALDH1A1USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | HSD17B10 305/4885KDM4E 3953/4885SLC2A1 96/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | HSD17B10 194/4885KDM4E 3347/4885SLC2A1 47/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.