Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 14/20 | 0.78 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.77 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.77 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.66 |
| ▸ | AKT1 | P31749 | 1/20 | 0.64 |
| ▸ | AKT2 | P31751 | 1/20 | 0.64 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.64 |
| ▸ | DRD4 | P21917 | 2/20 | 0.61 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.60 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.60 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.60 |
| ▸ | DRD1 | P21728 | 1/20 | 0.60 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.60 |
| ▸ | HTR7 | P34969 | 1/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.60 |
| ▸ | DRD3 | P35462 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3665096 | 0.87 | OPRM1 (1.00) | OPRM1OPRK1OPRL1AKT1AKT2 | |
| SCHEMBL20763210 | 0.85 | OPRM1 (1.00) | OPRM1OPRK1OPRL1AKT1AKT2 | |
| SCHEMBL7849321 | 0.84 | OPRM1 (1.00) | OPRM1OPRK1OPRL1AKT1AKT2 | |
| SCHEMBL22605775 | 0.83 | HSD11B1 (0.73) | OPRM1OPRK1OPRL1HSD11B1CHRM1 | |
| Oxalic Acid SCHEMBL5778025 | 0.83 | OPRM1 (0.91) | OPRM1OPRK1OPRL1AKT1AKT2 | |
| SCHEMBL8863557 | 0.83 | OPRM1 (0.91) | OPRM1OPRK1OPRL1AKT1AKT2 | |
| SCHEMBL12375874 | 0.82 | OPRM1 (0.77) | OPRM1OPRK1OPRL1AKT1AKT2 | |
| SCHEMBL1436457 | 0.81 | OPRM1 (0.79) | OPRM1OPRK1OPRL1AKT1AKT2 | |
| SCHEMBL3634015 | 0.81 | OPRM1 (0.83) | OPRM1OPRK1OPRL1AKT1AKT2 | |
| SCHEMBL7849288 | 0.81 | OPRM1 (0.76) | OPRM1OPRK1OPRL1AKT1AKT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6180649-B1 | NERVOUS SYSTEM DISORDERS; ALZHEIMER'S, HUNTINGTON, PARKINSON DISEASE | NEROSEARCH A/S (DK) | 2001-01-30 | — | — | US | claimed |
| EP-0898568-B1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH AS (DK) | 2006-10-04 | — | — | EP | disclosed |
| US-6180649-B1 | NERVOUS SYSTEM DISORDERS; ALZHEIMER'S, HUNTINGTON, PARKINSON DISEASE | NEROSEARCH A/S (DK) | 2001-01-30 | — | — | US | disclosed |
| EP-0898568-A1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH A/S (DK) | 1999-03-03 | — | — | EP | disclosed |
| WO-1997040035-A1 | 1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY | NEUROSEARCH A/S (DK) | 1997-10-30 | — | — | WO | disclosed |