Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TRPA1 | O75762 | 7/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5774618 | 1.00 | ALDH1A1 (0.46) | ALDH1A1LMNATP53MAPTKMT2A | |
| SCHEMBL613703 | 0.81 | HPGD (0.51) | ALDH1A1MAPTKMT2AMEN1 | |
| SCHEMBL11789535 | 0.80 | L3MBTL1 (0.46) | ALDH1A1LMNAMAPTKMT2ATRPA1 | |
| SCHEMBL11789537 | 0.80 | L3MBTL1 (0.46) | ALDH1A1LMNAMAPTKMT2ATRPA1 | |
| SCHEMBL5775659 | 0.79 | SMN1; SMN2 (0.53) | ALDH1A1TP53MAPTGAA | |
| SCHEMBL26156777 | 0.71 | TRPA1 (0.50) | ALDH1A1LMNAMAPTKMT2ATRPA1 | |
| SCHEMBL29253491 | 0.68 | ADRB1 (0.46) | ALDH1A1LMNAMAPTKMT2ASIGMAR1 | |
| SCHEMBL13069540 | 0.68 | ALDH1A1 (0.51) | ALDH1A1LMNATP53KMT2AGAA | |
| SCHEMBL4432627 | 0.67 | MAPT (0.48) | ALDH1A1LMNAMAPTKMT2ATRPA1 | |
| SCHEMBL13069008 | 0.67 | L3MBTL1 (0.55) | ALDH1A1LMNAMAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1054887-B1 | BICYCLIC PYRIDINE AND PYRIMIDINE DERIVATIVES AS NEUROPEPTIDE Y RECEPTOR ANTAGONISTS | AMGEN INC (US) | 2006-04-12 | — | — | EP | disclosed |
| US-6583154-B1 | Neuropeptide Y antagonist; pyrrolo-(3,2-b)pyridines and pyrrolo-(3,2-d)pyrimidines | AMGEN INC. | 2003-06-24 | — | — | US | disclosed |
| US-6187777-B1 | PYRROLO(3,2-D)PYRIMIDINE DERIVATIVES; NEUROPEPTIDE Y AND CORTICOTROPIN RELEASING FACTOR MODULATORS; DIETETICS; ANTIDIABETIC, ANTIINFLAMMATORY, AND ANTITUMOR AGENTS | AMGEN INC. | 2001-02-13 | — | — | US | disclosed |