Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | TEAD2 | Q15562 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | PTPRC | P08575 | 1/20 | 0.41 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | PTPA | Q15257 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | GCGR | P47871 | 1/20 | 0.40 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5775535 | 0.91 | CYP4F2 (0.42) | SMN1; SMN2KDM4EALDH1A1HPGDTEAD2 | |
| SCHEMBL5772630 | 0.89 | ALOX5 (0.51) | SMN1; SMN2KDM4EALDH1A1HPGDTEAD2 | |
| SCHEMBL5777151 | 0.89 | USP2 (0.44) | SMN1; SMN2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL5775425 | 0.86 | CYP4F2 (0.45) | SMN1; SMN2KDM4EALDH1A1HPGDTEAD2 | |
| SCHEMBL5770501 | 0.86 | USP2 (0.40) | SMN1; SMN2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL10668171 | 0.85 | SMN1; SMN2 (0.52) | SMN1; SMN2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL5774156 | 0.83 | CYP4F2 (0.45) | SMN1; SMN2KDM4EALDH1A1HPGDTEAD2 | |
| SCHEMBL5775490 | 0.83 | ALOX5 (0.52) | SMN1; SMN2KDM4EALDH1A1HPGDALOX5 | |
| SCHEMBL5770551 | 0.82 | SMN1; SMN2 (0.44) | SMN1; SMN2KDM4EALDH1A1HPGDNPC1 | |
| SCHEMBL11384351 | 0.82 | ALDH1A1 (0.48) | SMN1; SMN2KDM4EALDH1A1HPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | SMN1; SMN2 3383/4885KDM4E 3953/4885ALDH1A1 1045/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | SMN1; SMN2 2449/4885KDM4E 3347/4885ALDH1A1 682/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.