Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.44 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5776836 | 0.92 | PARP1 (0.44) | KMT2AMAPTMEN1TSHRL3MBTL1 | |
| Trifluoroacetic Acid SCHEMBL5775195 | 0.91 | ATM (0.49) | KMT2AMAPTL3MBTL1GFERAR | |
| Trifluoroacetic Acid SCHEMBL5772610 | 0.90 | GFER (0.53) | KMT2AMAPTMEN1LMNATSHR | |
| Trifluoroacetic Acid SCHEMBL5777370 | 0.90 | L3MBTL1 (0.55) | KMT2AMAPTMEN1LMNATSHR | |
| Trifluoroacetic Acid SCHEMBL5770010 | 0.88 | HTR1A (0.49) | KMT2AMAPTMEN1LMNATSHR | |
| Trifluoroacetic Acid SCHEMBL5777433 | 0.88 | GFER (0.53) | KMT2AMAPTMEN1LMNATSHR | |
| Trifluoroacetic Acid SCHEMBL5776691 | 0.86 | GRM5 (0.48) | MAPTTSHRNPC1ALDH1A1POLB | |
| Trifluoroacetic Acid SCHEMBL5774748 | 0.86 | ALDH1A1 (0.53) | KMT2ALMNATSHRNPC1RAB9A | |
| Trifluoroacetic Acid SCHEMBL5776834 | 0.85 | HTT (0.46) | KMT2AMAPTLMNAPOLBSMN1; SMN2 | |
| Trifluoroacetic Acid SCHEMBL5776822 | 0.85 | DPP8 (0.50) | KMT2AMAPTMEN1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | MOMOSE YU | 2006-04-20 | — | — | US | disclosed |
| US-7022725-B2 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2006-04-04 | — | — | US | disclosed |
| US-20040048908-A1 | Isoxazole derivatives | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2004-03-11 | — | — | US | disclosed |
| EP-1340749-A1 | ISOXAZOLE DERIVATIVES | Takeda Chemical Industries, Ltd. (JP) | 2003-09-03 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060084690-A1 | Isoxazole derivatives | INSR, GPR119, INSRR | KMT2A 3907/4885MAPT 4701/4885MEN1 2811/4885 |
| US-20040048908-A1 | Isoxazole derivatives | GPR119, INSR, IRS1 | KMT2A 2906/4885MAPT 4763/4885MEN1 2072/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.