Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.42 |
| ▸ | MC4R | P32245 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 2/20 | 0.39 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5776465 | 0.86 | CYP2A13 (0.44) | CYP3A4CYP2D6AKT1PIK3CDPIK3CA | |
| SCHEMBL5774994 | 0.82 | KDM4E (0.41) | SMN1; SMN2CYP3A4CYP2D6NOTUMKDM4E | |
| SCHEMBL5775730 | 0.82 | KDM4E (0.39) | NAMPTKDM4EMEN1KMT2ATAAR1 | |
| SCHEMBL18584701 | 0.81 | ABHD6 (0.43) | SMN1; SMN2HDAC8NOTUMKDM4EMEN1 | |
| SCHEMBL28901639 | 0.80 | ABHD6 (0.41) | SMN1; SMN2NOTUMKDM4EMEN1KMT2A | |
| SCHEMBL16268894 | 0.80 | S1PR5 (0.40) | SMN1; SMN2HDAC8NOTUMKDM4EMEN1 | |
| SCHEMBL22366387 | 0.78 | S1PR5 (0.42) | SMN1; SMN2NOTUMALDH1A1TAAR1ABHD6 | |
| SCHEMBL28245902 | 0.77 | S1PR5 (0.51) | SMN1; SMN2HDAC3HDAC1HDAC10HDAC11 | |
| SCHEMBL7107413 | 0.76 | MC4R (0.37) | MC4RNOTUMMEN1ALDH1A1KMT2A | |
| SCHEMBL22319819 | 0.76 | S1PR5 (0.47) | SMN1; SMN2NAMPTHDAC3HDAC1HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1483257-B1 | QUINAZOLINE COMPOUNDS USEFUL IN THERAPY | PFIZER LTD (GB) | 2006-09-13 | — | — | EP | disclosed |