Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.38 |
| ▸ | GPR3 | P46089 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.34 |
| ▸ | KMO | O15229 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2432403 | 0.83 | GPR3 (0.41) | HSD11B1GPR3ALDH1A1TSHR | |
| SCHEMBL10942037 | 0.83 | HSD11B1 (0.43) | HSD11B1ARSCN9ANOTUMTRPA1 | |
| SCHEMBL8379027 | 0.81 | HSD11B1 (0.44) | HSD11B1ARSCN9ACYP1A2CYP3A4 | |
| SCHEMBL8416356 | 0.81 | HSD11B1 (0.42) | HSD11B1GPR3AR | |
| SCHEMBL5323119 | 0.79 | CYP1A1 (0.39) | GPR3CYP1A2HPGD | |
| SCHEMBL1369845 | 0.78 | HSD11B1 (0.42) | HSD11B1ARSCN9ANOTUMCYP1A2 | |
| SCHEMBL15404637 | 0.78 | CYP24A1 (0.41) | HSD11B1CYP1A2CYP3A4TSHRTRPA1 | |
| SCHEMBL1320998 | 0.78 | L3MBTL1 (0.47) | HSD11B1GPR3SCN9ACYP3A4ALDH1A1 | |
| SCHEMBL9696764 | 0.78 | PDE2A (0.44) | ARALDH1A1TSHRHPGD | |
| SCHEMBL2049535 | 0.77 | HSD11B1 (0.35) | HSD11B1GPR3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615890-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | WARNER-LAMBERT COMPANY (US) | 2006-01-18 | — | — | EP | claimed |
| WO-2004089903-A1 | PIPERIDINE DERIVATIVES AS RENIN INHIBITORS FOR THE TREATMENT OF HYPERTENSION | WARNER-LAMBERT COMPANY LLC (US) | 2004-10-21 | — | — | WO | claimed |
| EP-0625520-B1 | Thiazolotriazole and thiazolodiazole derivatives with fungicidal activity | ISAGRO SPA (IT) | 1999-07-28 | — | — | EP | disclosed |
| US-5384325-A | Heterobicyclic derivatives with fungicidal activity | ISAGRO S.R.L. (IT) | 1995-01-24 | — | — | US | disclosed |
| EP-0625520-A2 | Thiazolotriazole and thiazolodiazole derivatives with fungicidal activity | ISAGRO S.r.l. (IT) | 1994-11-23 | — | — | EP | disclosed |