Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8865773 | 0.76 | — | — | |
| SCHEMBL5776467 | 0.73 | ALDH1A1 (0.44) | TSHR | |
| SCHEMBL417479 | 0.72 | — | — | |
| Hydrogen Sulfide SCHEMBL11480887 | 0.71 | TSHR (0.44) | TSHRCHKA | |
| SCHEMBL891486 | 0.67 | — | — | |
| SCHEMBL463754 | 0.66 | TSHR (0.73) | TSHRCHKA | |
| Hydrochloric Acid SCHEMBL30362247 | 0.65 | TSHR (0.41) | TSHR | |
| SCHEMBL13947387 | 0.65 | PDE4A (0.42) | TSHR | |
| SCHEMBL2324440 | 0.65 | AXL (0.40) | — | |
| SCHEMBL4596500 | 0.64 | RXRA (0.50) | TSHRCHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7482456-B2 | antiasthmatic; antiinflammatory; minimal side effects; 8-(3-{2-(3-chlorophenyl)-4-[4-(methylsulfonyl)phenyl]-1,3-thiazol-5-yl}phenyl)-6-[1-methyl-1-(methylsulfonyl)ethyl]quinoline; 2-[5-(3-{6-[1-methyl-1-(methylsulfonyl)ethyl]quinolin-8-yl}phenyl)-4-pyridin-3-yl-1,3-thiazol-2-yl]propan-2-ol | MERCK FROSST CANADA | 2009-01-27 | — | — | US | disclosed |
| EP-1635829-A1 | 8-(3-BIARYL)PHENYLQUINOLINE PHOSPHODIESTERASE-4-INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2006-03-22 | — | — | EP | disclosed |
| WO-2004096220-A1 | 8-(3-BIARYL)PHENYLQUINOLINE PHOSPHODIESTERASE-4-INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2004-11-11 | — | — | WO | disclosed |