Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 7/20 | 0.41 |
| ▸ | MAOA | P21397 | 6/20 | 0.41 |
| ▸ | AOC2 | O75106 | 5/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.41 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.41 |
| ▸ | DAO | P14920 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.39 |
| ▸ | RELA | Q04206 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10744654 | 0.78 | MAOB (0.42) | MAOBMAOAAOC2CHRM2CHRM4 | |
| SCHEMBL3230349 | 0.78 | HTR1A (0.45) | MAOBMAOANISCH | |
| SCHEMBL30211314 | 0.78 | HTR1A (0.45) | MAOBMAOANISCH | |
| Hydrochloric Acid SCHEMBL9668991 | 0.77 | HTR1A (0.44) | MAOBMAOANISCH | |
| SCHEMBL5722720 | 0.74 | MAOB (0.42) | MAOBMAOAAOC2CHRM2CHRM4 | |
| SCHEMBL29935960 | 0.74 | MAOB (0.42) | MAOBMAOAAOC2CHRM2CHRM4 | |
| SCHEMBL28327596 | 0.74 | MAOA (0.33) | MAOBMAOAAOC2CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL28624862 | 0.74 | AOC2 (0.43) | MAOBMAOAAOC2CHRM2CHRM4 | |
| SCHEMBL8470150 | 0.73 | BRD4 (0.50) | MAOBMAOAAOC2CHRM2CHRM4 | |
| SCHEMBL19268288 | 0.73 | MAOA (0.45) | MAOBMAOAAOC2CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4156936-A1 | ACTIVE COMPOUND COMBINATIONS | Bayer Aktiengesellschaft (DE) | 2023-04-05 | — | — | EP | disclosed |
| CN-109790122-A | Heterocyclic compound | 武田药品工业株式会社 | 2019-05-21 | — | — | CN | disclosed |
| CN-109563063-A | The method of 2, the 3- dihydro -1- benzofuran derivatives of 4- substitution is prepared by the cyclisation of 2- (phenyl that 2- diazonium -6 replaces) ethylate | 拜耳作物科学股份公司 | 2019-04-02 | — | — | CN | disclosed |
| CN-106588841-B | The method for synthesizing 2,3- dihydro -1- benzofuran -4- formaldehyde | 富乐马鸿凯（大连）医药有限公司 | 2019-01-25 | — | — | CN | disclosed |
| CN-108329285-A | A method of synthesis 2,3- Dihydrobenzofuranes class compounds | 武汉大学 | 2018-07-27 | — | — | CN | disclosed |
| CN-104910161-B | Pyrazolopyrimidine compound and method as JAK inhibitor | 健泰科生物技术公司 | 2018-03-30 | — | — | CN | disclosed |
| CN-104918935-B | dihydropyrazole GPR40 modulators | 百时美施贵宝公司 | 2017-07-28 | — | — | CN | disclosed |
| CN-106588841-A | Synthesis method of 2,3-dihydro-1-benzofuran-4-carbaldehyde | 大连鸿凯化工科技发展有限公司 | 2017-04-26 | — | — | CN | disclosed |
| CN-104244939-A | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof | CHDI FOUNDATION INC | 2014-12-24 | — | — | CN | disclosed |
| CN-102267964-B | 3-hydroxy-2,3-dihydro-benzofuran derivatives as well as synthesis method and application thereof | UNIV ZHEJIANG NORMAL | 2014-06-18 | — | — | CN | disclosed |
| CN-101374519-A | Modulators of muscarinic receptors | VERTEX PHARMA (US) | 2009-02-25 | — | — | CN | disclosed |
| CN-101031296-A | Modulators of muscarinic receptors | VERTEX PHARMA (US) | 2007-09-05 | — | — | CN | disclosed |
| CN-100335474-C | Preparation process for 2-oxocyclohexylidene acetate enol-lacton and application thereof | HOECHST FRANCE (FR) | 2007-09-05 | — | — | CN | disclosed |
| CN-1976705-A | 1,1, 1-trifluoro-4-phenyl-4-methyl-2- (1H-pyrrolo [2, 3-C ] pyridin-2-ylmethyl) pentan-2-ol derivatives and related compounds as glucocorticoid ligands for the treatment of inflammatory diseases and diabetes | BOEHRINGER INGELHEIM PHARMA (US) | 2007-06-06 | — | — | CN | disclosed |
| EP-1673088-A1 | 1,1,1- TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO¬2,3-C|PYRIDIN-2-YLMETHYL)PENTAN-2-OL DERIVATIVES AND RELATED COMPOUNDS AS GLUCOCORTICOID LIGANDS FOR THE TREATMENT OF INFLAMMATORY DISEASES AND DIABETES | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2006-06-28 | — | — | EP | disclosed |
| US-20050176706-A1 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-08-11 | — | — | US | disclosed |
| CN-1202102-C | Method for the production of 2-coumarone and substituted 2-coumarones | DSM FINE CHEM AUSTRIA GMBH (AT) | 2005-05-18 | — | — | CN | disclosed |
| WO-2005030213-A1 | 1,1,1-TRIFLUORO-4-PHENYL-4-METHYL-2-(1H-PYRROLO | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-04-07 | — | — | WO | disclosed |
| CN-1434815-A | Method for the production of 2-coumarone and substituted 2-coumarones | DSM FINE CHEM AUSTRIA GMBH (AT) | 2003-08-06 | — | — | CN | disclosed |
| CN-1014148-B | PROCESS FOR PREPARATION OF 2,3-DIHYDROBENZOFURAN-5-SULFONYLAMINE DERIVS. | SHIONOGI & CO (JP) | 1991-10-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050176706-A1 | Glucocorticoid mimetics, methods of making them, pharmaceutical compositions and uses thereof | NR3C1, NR3C2, MC2R | MAOB 2970/4885MAOA 3497/4885AOC2 4740/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.