Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | EED | O75530 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 6/20 | 0.34 |
| ▸ | HTR2A | P28223 | 6/20 | 0.34 |
| ▸ | DRD3 | P35462 | 6/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.34 |
| ▸ | MGAM | O43451 | 1/20 | 0.33 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5783494 | 0.86 | LMNA (0.40) | SMN1; SMN2MEN1ALDH1A1MAPTPKM | |
| SCHEMBL5599820 | 0.83 | SCN9A (0.37) | SMN1; SMN2MEN1ALDH1A1MAPTPKM | |
| SCHEMBL5598985 | 0.75 | MTNR1A (0.36) | ALDH1A1MAPTOPRM1HTR2A | |
| SCHEMBL5779729 | 0.75 | DRD2 (0.36) | SMN1; SMN2MEN1ALDH1A1MAPTPKM | |
| SCHEMBL5779471 | 0.70 | POLB (0.37) | MEN1MAPTKMT2APOLB | |
| SCHEMBL5579057 | 0.67 | HDAC1 (0.48) | SMN1; SMN2MEN1ALDH1A1MAPTPKM | |
| SCHEMBL5600810 | 0.64 | NPC1 (0.43) | SMN1; SMN2ALDH1A1KMT2ANPSR1LMNA | |
| SCHEMBL5592351 | 0.64 | HDAC1 (0.42) | SMN1; SMN2MEN1ALDH1A1KMT2AOPRM1 | |
| SCHEMBL916973 | 0.62 | FAAH (0.53) | SMN1; SMN2MEN1ALDH1A1MAPTPKM | |
| SCHEMBL5578870 | 0.61 | HCRTR1 (0.43) | MEN1ALDH1A1KMT2ALMNAOPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |