Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.34 |
| ▸ | TUBB | P07437 | 1/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.34 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.34 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.34 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.34 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.34 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.34 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5780283 | 0.98 | PTGDR2 (0.36) | DRD2DRD3PTGDR2DRD1CHRM1 | |
| SCHEMBL5599761 | 0.89 | CHRM1 (0.39) | DRD2DRD3PTGDR2CHRM1CHRM3 | |
| SCHEMBL5599289 | 0.86 | DRD2 (0.37) | DRD2PTGDR2CHRM1CHRM3CHRM2 | |
| SCHEMBL5783150 | 0.83 | PTGDR2 (0.36) | DRD2PTGDR2CHRM1CHRM3CHRM2 | |
| SCHEMBL5599571 | 0.80 | PTGDR2 (0.37) | DRD2PTGDR2CHRM1CHRM3CHRM2 | |
| SCHEMBL5600563 | 0.80 | TSHR (0.36) | DRD2PTGDR2CHRM1CHRM3CHRM2 | |
| SCHEMBL5599763 | 0.79 | DRD2 (0.38) | DRD2PTGDR2CHRM1CHRM3CHRM2 | |
| SCHEMBL5780173 | 0.79 | DRD2 (0.36) | DRD2PTGDR2DRD1CHRM1CHRM3 | |
| SCHEMBL5779582 | 0.77 | P2RX7 (0.41) | DRD2PTGDR2CHRM1CHRM3 | |
| SCHEMBL5782575 | 0.77 | GPR183 (0.34) | DRD2PTGDR2CHRM1CHRM3CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |