Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRD | O14764 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.31 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781810 | 0.90 | GNRHR (0.35) | — | |
| SCHEMBL5781993 | 0.86 | TPSAB1 (0.34) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL5599473 | 0.86 | TPSAB1 (0.34) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL5599673 | 0.83 | POLB (0.46) | SMN1; SMN2 | |
| SCHEMBL5781243 | 0.79 | CYP1A2 (0.36) | TP53 | |
| SCHEMBL5784794 | 0.79 | RXFP1 (0.42) | TP53 | |
| SCHEMBL5599482 | 0.77 | HTT (0.37) | SMN1; SMN2 | |
| SCHEMBL5599667 | 0.77 | ATM (0.37) | SMN1; SMN2 | |
| SCHEMBL5599757 | 0.75 | SIGMAR1 (0.40) | TP53SMN1; SMN2 | |
| SCHEMBL5781865 | 0.74 | BCHE (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1716148-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | Arena Pharmaceuticals, Inc. (US) | 2006-11-02 | — | — | EP | claimed |
| WO-2005063745-A2 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARMACEUTICALS, INC. (US) | 2005-07-14 | — | — | WO | claimed |