Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.34 |
| ▸ | TPSD1 | Q9BZJ3 | 2/20 | 0.34 |
| ▸ | TPSG1 | Q9NRR2 | 2/20 | 0.34 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5781993 | 1.00 | TPSAB1 (0.34) | TPSAB1TPSD1TPSG1GABRDGABRA1 | |
| SCHEMBL5785402 | 0.86 | GABRD (0.31) | GABRDGABRA1GABRB1GABRA5GABRA3 | |
| SCHEMBL5814088 | 0.79 | TACR1 (0.38) | SMN1; SMN2 | |
| SCHEMBL5599242 | 0.78 | CYP3A4 (0.38) | TP53SMN1; SMN2MEN1KMT2A | |
| SCHEMBL5599733 | 0.77 | HSD11B1 (0.40) | SMN1; SMN2 | |
| SCHEMBL5781810 | 0.76 | GNRHR (0.35) | — | |
| SCHEMBL5783158 | 0.74 | BCHE (0.38) | MEN1KMT2ABRD4 | |
| SCHEMBL5787489 | 0.73 | HSD11B1 (0.43) | MEN1KMT2A | |
| SCHEMBL5600630 | 0.72 | GNRHR (0.36) | — | |
| SCHEMBL5780895 | 0.72 | PSEN1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005063745-A9 | NOVEL SPIROINDOLINE OR SPIROISOQUINOLINE COMPOUNDS, METHODS OF USE AND COMPOSITIONS THEREOF | ARENA PHARM INC (US) | 2007-02-01 | — | — | WO | claimed |