Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PTGDR2 | Q9Y5Y4 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | CDK9 | P50750 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | STK10 | O94804 | 1/20 | 0.37 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.37 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7512743 | 0.77 | PTGS2 (0.46) | PTGS2SMN1; SMN2PTGS1 | |
| SCHEMBL4284342 | 0.75 | HTR7 (0.40) | SMN1; SMN2KMT2A | |
| SCHEMBL28986621 | 0.73 | PTGS2 (0.41) | PTGS2KMT2APTGDR2CYP11B1CYP11B2 | |
| SCHEMBL27732214 | 0.72 | PTGS2 (0.57) | PTGS2SMN1; SMN2PTGS1 | |
| SCHEMBL4637513 | 0.70 | PTGS2 (0.43) | PTGS2SMN1; SMN2PTGDR2CYP11B1CYP11B2 | |
| SCHEMBL13211354 | 0.70 | ALDH1A1 (0.63) | PTGS2SMN1; SMN2KMT2A | |
| SCHEMBL2885322 | 0.69 | CA1 (0.50) | SMN1; SMN2PTGS1 | |
| SCHEMBL6402326 | 0.68 | PTGS2 (0.52) | PTGS2SMN1; SMN2KMT2APTGS1 | |
| SCHEMBL2372578 | 0.68 | APP (0.47) | PTGS2SMN1; SMN2KMT2APTGS1 | |
| SCHEMBL11523591 | 0.68 | CYP1A1 (0.53) | SMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1660500-A1 | SUBSTITUTED IMIDAZOPYRIMIDINES FOR THE PREVENTION AND TREATMENT OF CANCER | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2006-05-31 | — | — | EP | disclosed |
| WO-2005014598-A1 | SUBSTITUTED IMIDAZOPYRIMIDINES FOR THE PREVENTION AND TREATMENT OF CANCER | LABORATORIOS S.A.L.V.A.T., S.A. (ES) | 2005-02-17 | — | — | WO | disclosed |