Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 3/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.44 |
| ▸ | FEN1 | P39748 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9114220 | 0.84 | TDP1 (0.50) | ALDH1A1MAPK1HIF1ATSHRCASP1 | |
| SCHEMBL14419355 | 0.84 | PRKAB2 (0.37) | ALDH1A1MAPK1HIF1ATSHRSMN1; SMN2 | |
| SCHEMBL10874236 | 0.83 | ALDH1A1 (0.52) | ALDH1A1MAPK1HIF1ATSHRCASP1 | |
| SCHEMBL9114275 | 0.82 | MAPT (0.51) | ALDH1A1MAPK1HIF1ATSHRCASP1 | |
| SCHEMBL9112200 | 0.82 | MAPT (0.51) | ALDH1A1MAPK1HIF1ATSHRCASP1 | |
| SCHEMBL5465739 | 0.82 | JAK2 (0.45) | ALDH1A1MAPK1MAPTTDP1GAA | |
| SCHEMBL513427 | 0.81 | TSHR (0.53) | ALDH1A1MAPK1HIF1ATSHRCASP1 | |
| SCHEMBL5786742 | 0.79 | ALDH1A1 (0.47) | ALDH1A1MAPK1HIF1ATSHRCASP1 | |
| SCHEMBL8196836 | 0.79 | SMN1; SMN2 (0.59) | ALDH1A1MAPK1HIF1ATSHRCASP1 | |
| SCHEMBL30209768 | 0.79 | SMN1; SMN2 (0.59) | ALDH1A1MAPK1HIF1ATSHRCASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7074791-B2 | Pyrrolo[1,2-b]pyridazine compounds and their uses | PFIZER INC. (US) | 2006-07-11 | — | — | US | disclosed |
| EP-1622911-A2 | PYRROLO[1,2-B]PYRIDAZINE COMPOUNDS AND THEIR USE AS CRF-1 RECEPTOR ANTAGONISTS | Pharmacia & Upjohn Company LLC (US) | 2006-02-08 | — | — | EP | disclosed |
| EP-1615929-A1 | PYRROLO [1,2-B] PYRIDAZINE COMPOUNDS AND THEIR USES | Pharmacia & Upjohn Company LLC (US) | 2006-01-18 | — | — | EP | disclosed |
| US-20040242587-A1 | Pyrrolo[1,2-b]pyridazine compounds | PFIZER INC | 2004-12-02 | — | — | US | disclosed |
| WO-2004099213-A2 | PYRROLO (1,2-B) PYRIDAZINE COMPOUNDS AND THEIR USE AS CRF-1 RECEPTOR ANTAGONISTS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-11-18 | — | — | WO | disclosed |
| WO-2004092176-A1 | PYRROLO[1,2-B]PYRIDAZINE COMPOUNDS AND THEIR USES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-10-28 | — | — | WO | disclosed |
| US-20040138221-A1 | Pyrrrolo[1,2-b]pyridazine compounds and their uses | PFIZER INC. | 2004-07-15 | — | — | US | disclosed |
| WO-2004035586-A1 | PYRROLO[1,2-B]PYRIDAZINE COMPOUNDS AND THEIR USES | PHARMACIA & UPJOHN COMPANY LLC (US) | 2004-04-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040138221-A1 | Pyrrrolo[1,2-b]pyridazine compounds and their uses | CRHR1, CRHR2, MC2R | ALDH1A1 1123/4885MAPK1 718/4885HIF1A 688/4885 |
| US-20040242587-A1 | Pyrrolo[1,2-b]pyridazine compounds | CRHR1, CRHR2, CRH | ALDH1A1 705/4885MAPK1 306/4885HIF1A 627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.