Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 6/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | CCR6 | P51684 | 1/20 | 0.47 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.44 |
| ▸ | HTT | P42858 | 4/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | GPR174 | Q9BXC1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5789763 | 1.00 | POLB (0.48) | POLBMEN1KMT2ANPC1CCR6 | |
| Ammonia Solution, Strong SCHEMBL5789879 | 0.82 | MAPT (0.50) | POLBMEN1KMT2ANPC1KDM1A | |
| Ammonia Solution, Strong SCHEMBL5789876 | 0.82 | MAPT (0.50) | POLBMEN1KMT2ANPC1KDM1A | |
| Ammonia Solution, Strong SCHEMBL5789965 | 0.77 | MAPT (0.57) | POLBMEN1KMT2ALMNAMAPT | |
| Ammonia Solution, Strong SCHEMBL5789960 | 0.77 | MAPT (0.57) | POLBMEN1KMT2ALMNAMAPT | |
| SCHEMBL13569080 | 0.74 | MAPT (0.65) | POLBMEN1KMT2ANPC1LMNA | |
| Ammonia Solution, Strong SCHEMBL5792939 | 0.72 | LMNA (0.54) | POLBKMT2ANPC1LMNAMAPT | |
| Ammonia Solution, Strong SCHEMBL5792944 | 0.72 | LMNA (0.54) | POLBKMT2ANPC1LMNAMAPT | |
| SCHEMBL5791695 | 0.71 | ALDH1A1 (0.51) | MEN1KMT2ALMNAALDH1A1KDM4E | |
| Ammonia Solution, Strong SCHEMBL5791250 | 0.70 | MAPT (0.67) | POLBMEN1KMT2ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006000294-A1 | NOVEL DIAZENIUMDIOLATE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | MERCK PATENT GMBH (DE) | 2006-01-05 | — | — | WO | claimed |
| WO-2006000294-A1 | NOVEL DIAZENIUMDIOLATE COMPOUNDS, PROCESS FOR THE PREPARATION THEREOF, AND THERAPEUTIC USE THEREOF | MERCK PATENT GMBH (DE) | 2006-01-05 | — | — | WO | disclosed |