Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 7/20 | 0.46 |
| ▸ | CTSB | P07858 | 6/20 | 0.46 |
| ▸ | CTSK | P43235 | 5/20 | 0.46 |
| ▸ | CTSS | P25774 | 5/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8270696 | 0.89 | CTSL (0.47) | CTSLCTSBCTSKCTSSFGFR4 | |
| SCHEMBL8268809 | 0.88 | CTSL (0.42) | CTSLCTSBCTSKCTSSFGFR4 | |
| SCHEMBL8269394 | 0.87 | CTSL (0.45) | CTSLCTSBCTSKCTSSFGFR4 | |
| SCHEMBL8269396 | 0.87 | CTSK (0.45) | CTSLCTSBCTSKCTSSFGFR4 | |
| SCHEMBL8268811 | 0.87 | TAS1R3 (0.40) | CTSLCTSBCTSKCTSSFGFR4 | |
| Trifluoroacetic Acid SCHEMBL5794344 | 0.86 | CTSL (0.43) | CTSLCTSBCTSKCTSSFGFR4 | |
| Trifluoroacetic Acid SCHEMBL5794600 | 0.85 | CTSL (0.41) | CTSLCTSBCTSKCTSSFGFR4 | |
| SCHEMBL8270505 | 0.85 | CTSK (0.42) | CTSLCTSBCTSKCTSSFGFR4 | |
| SCHEMBL8271456 | 0.85 | CTSK (0.47) | CTSLCTSBCTSKCTSSFGFR4 | |
| SCHEMBL5793933 | 0.84 | CTSK (0.39) | CTSLCTSBCTSKCTSSFGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |