Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 3/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | CTSB | P07858 | 1/20 | 0.45 |
| ▸ | CTSS | P25774 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.37 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | TRPV3 | Q8NET8 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | MLYCD | O95822 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL5794344 | 0.88 | CTSL (0.43) | CTSKCTSLCTSBCTSSFGFR4 | |
| SCHEMBL5791389 | 0.87 | CTSL (0.46) | CTSKCTSLCTSBCTSSFGFR4 | |
| SCHEMBL5794599 | 0.87 | CTSK (0.38) | CTSKCTSLCTSBCTSSMMP3 | |
| SCHEMBL8269394 | 0.86 | CTSL (0.45) | CTSKCTSLCTSBCTSSFGFR4 | |
| Trifluoroacetic Acid SCHEMBL5791067 | 0.85 | CTSL (0.41) | CTSKCTSLCTSBCTSSTRPM8 | |
| Trifluoroacetic Acid SCHEMBL5791991 | 0.84 | FPR2 (0.40) | IDO1 | |
| SCHEMBL8268809 | 0.82 | CTSL (0.42) | CTSKCTSLCTSBCTSSFGFR4 | |
| SCHEMBL8268851 | 0.82 | CTSL (0.42) | CTSKCTSLCTSBCTSSFGFR4 | |
| SCHEMBL5791497 | 0.81 | CTSK (0.42) | CTSKCTSLCTSBCTSSFGFR4 | |
| Trifluoroacetic Acid SCHEMBL5793410 | 0.80 | CTSK (0.65) | CTSKCTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |