Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 4/20 | 0.43 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.39 |
| ▸ | BRAF | P15056 | 4/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 3/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.38 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8271447 | 0.90 | CTSK (0.43) | CTSK | |
| SCHEMBL5791966 | 0.90 | CTSK (0.45) | CTSKCTSS | |
| SCHEMBL8271448 | 0.87 | CTSK (0.46) | CTSK | |
| SCHEMBL5790636 | 0.82 | CTSK (0.44) | CTSKMCHR1CTSS | |
| SCHEMBL8268844 | 0.81 | CTSK (0.45) | CTSKCTSS | |
| SCHEMBL5791503 | 0.81 | CTSK (0.47) | CTSKCTSS | |
| Trifluoroacetic Acid SCHEMBL5794693 | 0.77 | TSHR (0.38) | CTSKGPR139CTSS | |
| SCHEMBL8270467 | 0.77 | CTSK (0.48) | CTSKCTSS | |
| SCHEMBL8268811 | 0.77 | TAS1R3 (0.40) | CTSKTAS1R3TAS1R1CTSS | |
| SCHEMBL8270702 | 0.76 | NPC1 (0.46) | CTSKMCHR1CTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | claimed |
| WO-2006027211-A1 | 2,4-SUBSTITUTED PYRIMIDINES AS CYSTEINE PROTEASE INHIBITORS | GLAXO GROUP LIMITED (GB) | 2006-03-16 | — | — | WO | disclosed |